Primary human nasal epithelial cell response to titanium surface with a nanonetwork structure in nasal implant applications

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Title:	Primary human nasal epithelial cell response to titanium surface with a nanonetwork structure in nasal implant applications
Authors:	李勝偉;Yang, Wei-En;Lan, Ming-Ying;Lee, Sheng-Wei;Chang, Jeng-Kuei;Huang, Her-Hsiung
Contributors:	工學院材料科學與工程研究所
Keywords:	Chemistry and Materials Science;Cytoskeleton;Electrochemistry;Epithelial cells;Epithelium;Materials Science;Molecular Medicine;Nano Express;Nanochemistry;Nanoscale Science and Technology;Nanotechnology;Nanotechnology and Microengineering;Pore size;Protein adsorption;Surface properties;Surface treatment;Titanium;Titanium dioxide
Date:	2015-12-01
Issue Date:	2026-04-23 11:42:23 (UTC+8)
Publisher:	Springer New York;New York: Springer US
Abstract:	摘要： In nasal reconstruction applications, the response of cells to titanium (Ti) implants is largely determined by the surface characteristics of the implant. This study investigated an electrochemical anodization surface treatment intended to improve the response of primary human nasal epithelial cells (HNEpC) to Ti surfaces in nasal implant applications. We used a simple and fast electrochemical anodization treatment, i.e., applying anodic current, to produce a titanium dioxide (TiO 2 ) nanonetwork layer on the Ti surface with average lateral pore size below 100 nm, depending on the current applied. The TiO 2 nanonetwork layer exhibited enhanced hydrophilicity and protein adsorption ability compared with untreated Ti surfaces. In addition, the spreading morphology, cytoskeletal arrangement, and proliferation of HNEpC on the nanonetwork layer indicated excellent cell response characteristics. This research advances our understanding regarding the means by which a TiO 2 nanonetwork layer can improve the response of HNEpC to Ti surfaces in nasal implant applications. 其他題名： Nanoscale Res Lett 出版者： New York: Springer US 出版日期： 2015-12 出處： Nanoscale research letters, 2015-12, Vol.10 (1), p.167, Article 167 資源來源： Publicly Available Content Database (Proquest) 版權： Yang et al.; licensee Springer. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. 版權： Copyright Springer Nature B.V. Dec 2015 版權： Yang et al.; licensee Springer. 2015 識別號： ISSN: 1931-7573 識別號： ISSN: 1556-276X 識別號： EISSN: 1556-276X 識別號： DOI: 10.1186/s11671-015-0849-8 識別號： PMID: 25977647
Appears in Collections:	[Institute of Materials Science and Engineering] journal & Dissertation

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