資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.lib.ncu.edu.tw/handle/987654321/104092
|
| 題名: | Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells |
| 作者: | 陳一塵;Cheng, Po-Ching;Huang, Chun-Chih;Chiang, Ping-Fang;Lin, Ching-Nan;Li, Li-Li;Lee, Te-Wei;Lin, Bin;Chen, I-Chen;Chang, Kang-Wei;Fan, Chia-Kwung;Luo, Tsai-Yueh |
| 貢獻者: | 工學院材料科學與工程研究所 |
| 關鍵詞: | Animals;Antrodia - chemistry;Antrodia cinnamomea;apoptosis;Apoptosis - drug effects;Apoptosis - immunology;Apoptosis - radiation effects;cancer;Cell Line, Tumor;Cell Survival - drug effects;Cell Survival - immunology;Cell Survival - radiation effects;Cells, Cultured;Cytokines - immunology;Dose-Response Relationship, Drug;HT29 Cells;Humans;Leukocytes - drug effects;Leukocytes - immunology;Leukocytes - radiation effects;Male;Mice;Mice, Inbred BALB C;Neoplasms, Experimental - immunology;Radiation Dosage;radiation side-effects;Radiation Tolerance - drug effects;Radiation-Protective Agents - administration & dosage;radioprotection |
| 日期: | 2014-10-01 |
| 上傳時間: | 2026-04-23 11:43:25 (UTC+8) |
| 出版者: | England: Informa Healthcare |
| 摘要: | 摘要： Abstract Purpose: The radioprotective effects of Antrodia cinnamomea (AC) were investigated for understanding the potential usefulness of AC as an adjunct treatment for reducing radiation side-effects. Materials and methods: In this study, we determined the ability of AC extracts (AC539) to reduce radiation side-effects by analyzing cellular viability in normal mouse spleen immune cells and human cancer cells with different radiosensitivity. We further detected the effect of AC on radiation-induced changes in cytokine- and inflammatory-related gene expressions. Furthermore, apoptosis assay was performed to determine whether AC could inhibit radiation-induced cytotoxicity. Results: We found that an AC dose of 100-150 μg/ml in a time-dependent manner was the most effective in blocking radiation-induced cytotoxicity, in vitro. Radiation-induced cytotoxicity was inhibited in spleen immune cells by 37-56%; however, pretreatment of human colorectal cancer cell line HT-29 with AC did not have any effect on radiation-induced cytotoxicity, while pretreatment of radiosensitive human breast cancer cell lines BT-474 with AC caused a moderate enhancement of radiation-induced damage. Furthermore, AC pretreatment differentially regulated the mRNA expression of several important immunomodulatory genes in response to irradiation in normal and cancer cells. Conclusions: Our data indicate that AC may inhibit important immunoregulatory signaling which could be vital in the avoidance of an over-activated cytotoxic and inflammatory response of the immune system caused by radiation-induced tissue damage. Additionally, AC does not provide a radioprotective effect to tumor cells but instead enhances radiation-induced inflammation and cytotoxicity in cancer.
其他題名： Int J Radiat Biol
出版者： England: Informa Healthcare
出版日期： 2014-10
出處： International journal of radiation biology, 2014-10, Vol.90 (10), p.841-852
資源來源： EBSCOhost Academic Search Premier
版權： 2014 Informa UK, Ltd. 2014
識別號： ISSN: 0955-3002
識別號： ISSN: 1362-3095
識別號： EISSN: 1362-3095
識別號： DOI: 10.3109/09553002.2014.911989
識別號： PMID: 24708166 |
| 顯示於類別: | [材料科學與工程研究所 ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 19 | 檢視/開啟 |
|
在NCUIR中所有的資料項目都受到原著作權保護.
|
