Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells

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題名:	Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells
作者:	陳一塵;Cheng, Po-Ching;Huang, Chun-Chih;Chiang, Ping-Fang;Lin, Ching-Nan;Li, Li-Li;Lee, Te-Wei;Lin, Bin;Chen, I-Chen;Chang, Kang-Wei;Fan, Chia-Kwung;Luo, Tsai-Yueh
貢獻者:	工學院材料科學與工程研究所
關鍵詞:	Animals;Antrodia - chemistry;Antrodia cinnamomea;apoptosis;Apoptosis - drug effects;Apoptosis - immunology;Apoptosis - radiation effects;cancer;Cell Line, Tumor;Cell Survival - drug effects;Cell Survival - immunology;Cell Survival - radiation effects;Cells, Cultured;Cytokines - immunology;Dose-Response Relationship, Drug;HT29 Cells;Humans;Leukocytes - drug effects;Leukocytes - immunology;Leukocytes - radiation effects;Male;Mice;Mice, Inbred BALB C;Neoplasms, Experimental - immunology;Radiation Dosage;radiation side-effects;Radiation Tolerance - drug effects;Radiation-Protective Agents - administration & dosage;radioprotection
日期:	2014-10-01
上傳時間:	2026-04-23 11:43:25 (UTC+8)
出版者:	England: Informa Healthcare
摘要:	摘要： Abstract Purpose: The radioprotective effects of Antrodia cinnamomea (AC) were investigated for understanding the potential usefulness of AC as an adjunct treatment for reducing radiation side-effects. Materials and methods: In this study, we determined the ability of AC extracts (AC539) to reduce radiation side-effects by analyzing cellular viability in normal mouse spleen immune cells and human cancer cells with different radiosensitivity. We further detected the effect of AC on radiation-induced changes in cytokine- and inflammatory-related gene expressions. Furthermore, apoptosis assay was performed to determine whether AC could inhibit radiation-induced cytotoxicity. Results: We found that an AC dose of 100-150 μg/ml in a time-dependent manner was the most effective in blocking radiation-induced cytotoxicity, in vitro. Radiation-induced cytotoxicity was inhibited in spleen immune cells by 37-56%; however, pretreatment of human colorectal cancer cell line HT-29 with AC did not have any effect on radiation-induced cytotoxicity, while pretreatment of radiosensitive human breast cancer cell lines BT-474 with AC caused a moderate enhancement of radiation-induced damage. Furthermore, AC pretreatment differentially regulated the mRNA expression of several important immunomodulatory genes in response to irradiation in normal and cancer cells. Conclusions: Our data indicate that AC may inhibit important immunoregulatory signaling which could be vital in the avoidance of an over-activated cytotoxic and inflammatory response of the immune system caused by radiation-induced tissue damage. Additionally, AC does not provide a radioprotective effect to tumor cells but instead enhances radiation-induced inflammation and cytotoxicity in cancer. 其他題名： Int J Radiat Biol 出版者： England: Informa Healthcare 出版日期： 2014-10 出處： International journal of radiation biology, 2014-10, Vol.90 (10), p.841-852 資源來源： EBSCOhost Academic Search Premier 版權： 2014 Informa UK, Ltd. 2014 識別號： ISSN: 0955-3002 識別號： ISSN: 1362-3095 識別號： EISSN: 1362-3095 識別號： DOI: 10.3109/09553002.2014.911989 識別號： PMID: 24708166
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