Rapid screening of potential metallic glasses for biomedical applications

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Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/104100

Title:	Rapid screening of potential metallic glasses for biomedical applications
Authors:	鄭憲清;Lin, C.H.;Huang, C.H.;Chuang, J.F.;Huang, J.C.;Jang, J.S.C.;Chen, C.H.
Contributors:	工學院材料科學與工程研究所
Keywords:	Alloys - chemistry;Alloys - toxicity;Animals;Bone Marrow Cells - cytology;Cell Survival - drug effects;Cells, Cultured;Cytotoxicity;Electrochemical activity;Electrochemical Techniques;Glass - chemistry;Humans;Ions - chemistry;Metallic glasses;Metals - chemistry;Mice;MTT test;Potential state;Stem Cells - cytology
Date:	2013-12-01
Issue Date:	2026-04-23 11:43:33 (UTC+8)
Publisher:	Elsevier BV;Netherlands: Elsevier B.V
Abstract:	摘要： This paper presents a rapid screening process to select potential titanium and zirconium based metallic glasses (MGs) for bio-material applications. Electrochemical activity of 7 MGs including 6 bulk metallic glasses and 1 thin-film deposited MG in simulation body and human serum is first inspected. A low-voltage potential state test is also developed to simulate the cell membrane potential that the implant MGs will suffer. Results show that the MGs composed of Ti65Si15Ta10Zr10 and Ta57Zr23Cu12Ti8 exhibit excellent electrochemical stability in both simulation body fluid and human serum. In addition, the copper content in the MGs plays an important role on the electrochemical activity. MGs with the copper content higher than 17.5% show significant electrochemical responses. The cytotoxicity of the solid MG samples and the corrosion released ions are also evaluated by an in-vitro MTT test utilizing the murine bone marrow stem cells. Results indicate that all the solid MG samples show no acute cytotoxicity yet the corrosion released ions show significant toxicity for murine bone marrow stem cells. The rapid screening process developed in the present study suggests that the Ti65Si15Ta10Zr10 metallic glass has high potential for biomedical applications due to its good electrochemical stability and very low cytotoxicity. [Display omitted] •A rapid electrochemical cycle screening process is proposed.•This process can select potential metallic glasses for bio-material applications.•The Ti65Si15Ta10Zr10 metallic glass exhibits the best response and high potential. 其他題名： Mater Sci Eng C Mater Biol Appl 出版者： Netherlands: Elsevier B.V 出版日期： 2013-12-01 出處： Materials Science & Engineering C, 2013-12, Vol.33 (8), p.4520-4526 資源來源： Elsevier ScienceDirect Journals Complete 版權： 2013 Elsevier B.V. 版權： 2013. 識別號： ISSN: 0928-4931 識別號： ISSN: 1873-0191 識別號： EISSN: 1873-0191 識別號： DOI: 10.1016/j.msec.2013.07.006 識別號： PMID: 24094154
Appears in Collections:	[Institute of Materials Science and Engineering] journal & Dissertation

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