Differential protein partitioning within the herpesvirus tegument and envelope underlies a complex and variable virion architecture

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题名:	Differential protein partitioning within the herpesvirus tegument and envelope underlies a complex and variable virion architecture
作者:	田溶根;Bohannon, Kevin Patrick;Jun, Yonggun;Gross, Steven P.;Smith, Gregory Allan
贡献者:	理學院物理學系
关键词:	Animals;Biological Sciences;capsid;Cell Line;Chromosomes, Artificial, Bacterial;Fluorescence;Herpes viruses;Herpesvirus 1, Suid - genetics;Herpesvirus 1, Suid - metabolism;Herpesvirus 1, Suid - ultrastructure;image analysis;Microscopy, Fluorescence;Models, Molecular;Mutagenesis;PNAS Plus;Proteins;Swine;Viral Structural Proteins - genetics;Viral Structural Proteins - metabolism;virion;Virion - genetics;Virion - ultrastructure
日期:	2013-04-23
上传时间:	2026-04-23 11:51:28 (UTC+8)
出版者:	National Academy of Sciences;United States: National Academy of Sciences
摘要:	摘要： The herpesvirus virion is a multilayered structure consisting of a DNA-filled capsid, tegument, and envelope. Detailed reconstructions of the capsid are possible based on its icosahedral symmetry, but the surrounding tegument and envelope layers lack regular architecture. To circumvent limitations of symmetry-based ultrastructural reconstruction methods, a fluorescence approach was developed using single-particle imaging combined with displacement measurements at nanoscale resolution. An analysis of 11 tegument and envelope proteins defined the composition and plasticity of symmetric and asymmetric elements of the virion architecture. The resulting virion protein map ascribes molecular composition to density profiles previously acquired by traditional ultrastructural methods, and provides a way forward to examine the dynamics of the virion architecture during infection. 其他題名： Proc Natl Acad Sci U S A 出版者： United States: National Academy of Sciences 出版日期： 2013-04-23 出處： Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (17), p.E1613-E1620 資源來源： JSTOR Life Sciences Collection 版權： Copyright National Academy of Sciences Apr 23, 2013 識別號： ISSN: 0027-8424 識別號： ISSN: 1091-6490 識別號： EISSN: 1091-6490 識別號： DOI: 10.1073/pnas.1221896110 識別號： PMID: 23569236
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