Analysis of flavonoids by graphene-based surface-assisted laser desorption/ionization time-of-flight mass spectrometry

NCUIR > Engineering College > Energy of Mechatronics > journal & Dissertation > Item 987654321/104722

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/104722

Title:	Analysis of flavonoids by graphene-based surface-assisted laser desorption/ionization time-of-flight mass spectrometry
Authors:	蘇清源;Liu, Chih-Wei;Chien, Min-Wei;Su, Ching-Yuan;Chen, Hui-Yi;Li, Lain-Jong;Lai, Chien-Chen
Contributors:	工學院能源工程研究所
Date:	2012-12-21
Issue Date:	2026-04-23 11:56:27 (UTC+8)
Publisher:	Royal Society of Chemistry
Abstract:	摘要： Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a simple and fast technique for the analysis of large biomolecules but is not suitable for the detection of low molecular weight molecules and compounds, such as flavonoids and phenylpropanoids, mainly due to the lack of an appropriate matrix. Flavonoids and phenylpropanoids, such as coumarin and its derivatives, have attracted much attention recently because of their pharmacological activities and putative therapeutic benefits. In this study, we developed a quick and simple LDI-TOF MS method for the detection of flavonoids and the derivatives of coumarin. Analytes were spotted onto a matrix of graphene-based nanoparticles and then analyzed by LDI-TOF MS in the negative ion mode. Analysis of the sensitivity and effect of different graphene-based nanoparticles including graphene, graphene oxide, and reduced graphene oxide on desorption/ionization of analytes showed that graphene oxide was the most suitable matrix. Moreover, we found that graphene oxide sheets of larger lateral size resulted in better desorption/ionization efficiency. Overall, we show that graphene oxide is a useful matrix for the analysis of flavonoids and the derivatives of coumarin by LDI-TOF MS in the negative ion mode. A quick and simple graphene nanoparticle-based SALDI-TOF MS method for the detection of flavonoids in the negative ion mode. 出版日期： 2012-11-12 資源來源： Royal Society of Chemistry 識別號： ISSN: 0003-2654 識別號： EISSN: 1364-5528 識別號： DOI: 10.1039/c2an36155h
Appears in Collections:	[Energy of Mechatronics] journal & Dissertation

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