American Physical Society;United States: American Physical Society (APS)
摘要:
摘要： A theoretical model for stratified epithelium is presented. The viscoelastic properties of the tissue are assumed to be dependent on the spatial distribution of proliferative and differentiated cells. Based on this assumption, a hydrodynamic description of tissue dynamics at the long-wavelength, long-time limit is developed, and the analysis reveals important insights into the dynamics of an epithelium close to its steady state. When the proliferative cells occupy a thin region close to the basal membrane, the relaxation rate towards the steady state is enhanced by cell division and cell apoptosis. On the other hand, when the region where proliferative cells reside becomes sufficiently thick, a flow induced by cell apoptosis close to the apical surface enhances small perturbations. This destabilizing mechanism is general for continuous self-renewal multilayered tissues; it could be related to the origin of certain tissue morphology, tumor growth, and the development pattern. 其他題名： Phys Rev E 出版者： United States: American Physical Society (APS) 出版日期： 2016-05-31 出處： Physical Review E, 2016-05, Vol.93 (5), p.052421, Article 052421 識別號： ISSN: 2470-0045 識別號： ISSN: 2470-0053 識別號： EISSN: 2470-0053 識別號： DOI: 10.1103/physreve.93.052421 識別號： PMID: 27300937
