Ionic characteristics in cardiac alternans suppression using T � feedback control

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題名:	Ionic characteristics in cardiac alternans suppression using T � feedback control
作者:	黎璧賢;Liang, Shiuan-Ni;Le, Duy-Manh;Lai, Pik-Yin;Chan, C. K.
貢獻者:	理學院物理學系
關鍵詞:	05.45.-a;05.45.Gg;87.19.Hh;Alternan;Calcium;Control systems;Feedback control
日期:	2016-08-01
上傳時間:	2026-04-23 12:07:22 (UTC+8)
出版者:	Les Ulis: EDP Sciences, IOP Publishing and Societ� Italiana di Fisica
摘要:	摘要： Using the Luo-Rudy I model, the recently proposed $T\pm \epsilon$ feedback control for suppressing cardiac alternans is investigated. It is shown that cardiac alternans, induced by fast pacing (of period T), can be dramatically reduced by small changes of fixed magnitude (ϵ) under feedback control when ϵ exceeds a critical threshold. Detail information on various ionic currents and cytosolic calcium concentration $\big([\text{Ca}]_{\text{i}}\big)$ are examined when the cardiac cell is under control. In particular, the alternans in ionic currents and [Ca]i are also reduced under the control. Furthermore, when ϵ exceeds the threshold value, the average [Ca]i level is significantly higher when the alternans is under control, suggesting a possible physiological improvement of cardiac contractions. 出版者： Les Ulis: EDP Sciences, IOP Publishing and Società Italiana di Fisica 出版日期： 2016-08 出處： Europhysics letters, 2016-08, Vol.115 (4), p.48001 資源來源： Institute of Physics Journals 版權： Copyright © EPLA, 2016 識別號： ISSN: 0295-5075 識別號： EISSN: 1286-4854 識別號： DOI: 10.1209/0295-5075/115/48001
顯示於類別:	[物理學系] 期刊論文

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