Mechanism and kinetics of a sodium-driven bacterial flagellar motor

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/105466

Title:	Mechanism and kinetics of a sodium-driven bacterial flagellar motor
Authors:	羅健榮;Lo, Chien-Jung;Sowa, Yoshiyuki;Pilizota, Teuta;Berry, Richard M.
Contributors:	理學院物理學系
Keywords:	Bacteria;bacterial motility;Bacterial Physiological Phenomena;Biological Sciences;cell walls;Chemical potential;Electrochemistry;Flagella;Flagella - physiology;Ions;Kinetics;Membranes;Molecules;PNAS Plus;Sodium;Sodium - physiology;Swimming
Date:	2013-07-09
Issue Date:	2026-04-23 12:29:52 (UTC+8)
Publisher:	National Academy of Sciences;United States: National Academy of Sciences
Abstract:	摘要： The bacterial flagellar motor is a large rotary molecular machine that propels swimming bacteria, powered by a transmembrane electrochemical potential difference. It consists of an ∼50-nm rotor and up to ∼10 independent stators anchored to the cell wall. We measured torque–speed relationships of single-stator motors under 25 different combinations of electrical and chemical potential. All 25 torque–speed curves had the same concave-down shape as fully energized wild-type motors, and each stator passes at least 37 ± 2 ions per revolution. We used the results to explore the 25-dimensional parameter space of generalized kinetic models for the motor mechanism, finding 830 parameter sets consistent with the data. Analysis of these sets showed that the motor mechanism has a “powerstroke” in either ion binding or transit; ion transit is channel-like rather than carrier-like; and the rate-limiting step in the motor cycle is ion binding at low concentration, ion transit, or release at high concentration. 其他題名： Proc Natl Acad Sci U S A 出版者： United States: National Academy of Sciences 出版日期： 2013-07-09 出處： Proceedings of the National Academy of Sciences, 2013-07, Vol.110 (28), p.E2544-E2551 資源來源： JSTOR Life Sciences Collection 版權： Copyright National Academy of Sciences Jul 9, 2013 識別號： ISSN: 0027-8424 識別號： ISSN: 1091-6490 識別號： EISSN: 1091-6490 識別號： DOI: 10.1073/pnas.1301664110 識別號： PMID: 23788659
Appears in Collections:	[Department of Physics] journal & Dissertation

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