7,7′′-Dimethoxyagastisflavone-induced apoptotic or autophagic cell death in different cancer cells

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Title:	7,7′′-Dimethoxyagastisflavone-induced apoptotic or autophagic cell death in different cancer cells
Authors:	吳忻怡;Hwang, Chia-Hsiang;Lin, Yu-Ling;Liu, Yen-Ku;Chen, Chia-Hung;Wu, Hsin-Yi;Chang, Cheng-Chang;Chang, Chao-Yuan;Chang, Yu-Kuo;Chiu, Yi-Han;Liao, Kuang-Wen;Lai, Yiu-Kay
Contributors:	總教學中心通識教育中心
Keywords:	7,7′′‐dimethoxyagastisflavone;7′′-dimethoxyagastisflavone;Alkaloids;Alkaloids - isolation & purification;Antineoplastic Agents, Phytogenic;Antineoplastic Agents, Phytogenic - isolation & purification;Antineoplastic Agents, Phytogenic - pharmacology;Apoptosis;Autophagy;biflavonoid;Biflavonoids;Biflavonoids - isolation & purification;Biflavonoids - pharmacology;Biological and medical sciences;Biomarkers, Tumor;Biomarkers, Tumor - metabolism;Caspase 3;Caspase 3 - metabolism;Cell Survival;chemistry;Chromatography, High Pressure Liquid;colorectal neoplasms;drug effects;Enzyme Activation;General pharmacology;Hep G2 Cells;hepatoma;HT29 Cells;human cell lines;Humans;Inhibitory Concentration 50;isolation & purification;lung neoplasms;Medical sciences;membrane potential;Membrane Potential, Mitochondrial;metabolism;Mitochondria;Mitochondria - drug effects;Mitochondria - metabolism;Pharmacognosy. Homeopathy. Health food;pharmacology;Pharmacology. Drug treatments;Taxoids;Taxoids - isolation & purification;Taxus;Taxus - chemistry;Taxus media;Taxus × media cv. Hicksii
Date:	2012-04-01
Issue Date:	2026-04-23 12:52:21 (UTC+8)
Publisher:	John Wiley and Sons Ltd;Chichester, UK: John Wiley & Sons, Ltd
Abstract:	摘要： 7,7′′‐Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from the needles of Taxus × media cv. Hicksii, was evaluated for its antiproliferative and antineoplastic effects in three human cancer cell lines. Interestingly, DMGF caused cell death via different pathways in different cancer cells. DMGF induced apoptosis, activated caspase‐3 activity and changed the mitochondrial membrane potential in HT‐29 human colon cancer cells. However, the apoptotic pathway is not the major pathway involved in DMGF‐induced cell death in A549 human lung cancer cells and HepG2 human hepatoma cells. Treatment with 3‐MA, an inhibitor of autophagy, significantly decreased DMGF‐induced cell death in HepG2 and A549 cells, but did not affect DMGF‐induced cell death in HT‐29 cells. Following DMGF treatment, the HepG2 cells increased expression of LC3B‐II, a marker used to monitor autophagy in cells. Thus, DMGF induced apoptotic cell death in HT‐29 cells, triggered both apoptotic and autophagic death in A549 cells and induced autophagic cell death in HepG2 cells. Copyright © 2011 John Wiley & Sons, Ltd. 其他題名： Phytother. Res 出版者： Chichester, UK: John Wiley & Sons, Ltd 出版日期： 2012-04 出處： Phytotherapy research, 2012-04, Vol.26 (4), p.528-534 資源來源： Wiley Online Library - AutoHoldings Journals 版權： Copyright © 2011 John Wiley & Sons, Ltd. 版權： 2015 INIST-CNRS 識別號： ISSN: 0951-418X 識別號： ISSN: 1099-1573 識別號： EISSN: 1099-1573 識別號： DOI: 10.1002/ptr.3583 識別號： PMID: 21915931
Appears in Collections:	[Center for General Education ] journal & Dissertation

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