Decoding the disease-associated proteins encoded in the human chromosome 4

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Title:	Decoding the disease-associated proteins encoded in the human chromosome 4
Authors:	吳忻怡;Chen, Lien-Chin;Liu, Mei-Ying;Hsiao, Yung-Chin;Choong, Wai-Kok;Wu, Hsin-Yi;Hsu, Wen-Lian;Liao, Pao-Chi;Sung, Ting-Yi;Tsai, Shih-Feng;Yu, Jau-Song;Chen, Yu-Ju
Contributors:	總教學中心通識教育中心
Keywords:	biomarkers;chromosomes;Chromosomes, Human, Pair 4 - classification;Chromosomes, Human, Pair 4 - genetics;Computational Biology;Databases, Protein;Disease - classification;Disease - genetics;drugs;genetic disorders;genetic markers;Genome, Human;growth factors;hepatoma;Human Genome Project;Humans;immune system;membrane proteins;metabolic diseases;monitoring;oncogenes;Pilot Projects;protein isoforms;Proteins - classification;Proteins - genetics;Proteins - metabolism;proteome;Proteomics;single nucleotide polymorphism;stem cells;topology
Date:	2013-01-04
Issue Date:	2026-04-23 12:52:45 (UTC+8)
Publisher:	American Chemical Society;United States: American Chemical Society
Abstract:	摘要： Chromosome 4 is the fourth largest chromosome, containing approximately 191 megabases (∼6.4% of the human genome) with 757 protein-coding genes. A number of marker genes for many diseases have been found in this chromosome, including genetic diseases (e.g., hepatocellular carcinoma) and biomedical research (cardiac system, aging, metabolic disorders, immune system, cancer and stem cell) related genes (e.g., oncogenes, growth factors). As a pilot study for the chromosome 4-centric human proteome project (Chr 4-HPP), we present here a systematic analysis of the disease association, protein isoforms, coding single nucleotide polymorphisms of these 757 protein-coding genes and their experimental evidence at the protein level. We also describe how the findings from the chromosome 4 project might be used to drive the biomarker discovery and validation study in disease-oriented projects, using the examples of secretomic and membrane proteomic approaches in cancer research. By integrating with cancer cell secretomes and several other existing databases in the public domain, we identified 141 chromosome 4-encoded proteins as cancer cell-secretable/shedable proteins. Additionally, we also identified 54 chromosome 4-encoded proteins that have been classified as cancer-associated proteins with successful selected or multiple reaction monitoring (SRM/MRM) assays developed. From literature annotation and topology analysis, 271 proteins were recognized as membrane proteins while 27.9% of the 757 proteins do not have any experimental evidence at the protein-level. In summary, the analysis revealed that the chromosome 4 is a rich resource for cancer-associated proteins for biomarker verification projects and for drug target discovery projects. 其他題名： J. Proteome Res 出版者： United States: American Chemical Society 出版日期： 2013-01-04 出處： Journal of proteome research, 2013-01, Vol.12 (1), p.33-44 資源來源： American Chemical Society Journals 版權： Copyright © 2012 American Chemical Society 識別號： ISSN: 1535-3893 識別號： ISSN: 1535-3907 識別號： EISSN: 1535-3907 識別號： DOI: 10.1021/pr300829r 識別號： PMID: 23256888
Appears in Collections:	[Center for General Education ] journal & Dissertation

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