Inhibitory effects of chloroform extracts derived from corbicula fluminea on the release of pro-inflammatory cytokines

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Title:	Inhibitory effects of chloroform extracts derived from corbicula fluminea on the release of pro-inflammatory cytokines
Authors:	吳忻怡;Lin, Ching-Min;Lin, Yu-Ling;Tsai, Nu-Man;Wu, Hsin-Yi;Ho, Shu-Yi;Chen, Chia-Hung;Liu, Yen-Ku;Chiu, Yi-Han;Ho, Li-Ping;Lee, Ru-Ping;Liao, Kuang-Wen
Contributors:	總教學中心通識教育中心
Keywords:	Animals;antagonists & inhibitors;anti-inflammatory activity;Anti-Inflammatory Agents;Anti-Inflammatory Agents - isolation & purification;Anti-Inflammatory Agents - metabolism;Anti-Inflammatory Agents - pharmacology;Biological and medical sciences;Cell Line;Cells, Cultured;chemistry;Chloroform;clams;Corbicula;Corbicula - chemistry;Corbicula - metabolism;Corbicula fluminea;Cytokines;Cytokines - antagonists & inhibitors;Cytokines - immunology;drug therapy;fatty acids;Food industries;functional foods;Fundamental and applied biological sciences. Psychology;gas chromatography;gene expression;hepatitis;Humans;immunology;inflammation;Inflammation - drug therapy;Inflammation - immunology;Inflammation Mediators;Inflammation Mediators - antagonists & inhibitors;Inflammation Mediators - immunology;isolation & purification;lipopolysaccharides;mass spectrometry;messenger RNA;metabolism;Mice;Mice, Inbred BALB C;pharmacology;phosphorylation;phytosterols;quantitative polymerase chain reaction;Rats, Inbred WKY;Taiwan;tumor necrosis factor-alpha;Western blotting
Date:	2012-04-25
Issue Date:	2026-04-23 12:53:31 (UTC+8)
Publisher:	American Chemical Society;Washington, DC: American Chemical Society
Abstract:	摘要： Corbicula fluminea, the primary freshwater bivalve cultivated in Taiwan, was formerly used as a remedy for hepatitis. Recent reports indicate that C. fluminea has many bioactivities, but it remains unknown whether C. fluminea affects inflammation. This study explored the anti-inflammatory activity of C. fluminea. C. fluminea was first treated with chloroform to obtain clam chloroform extracts (CCEs). On the basis of the assay for the release of pro-inflammatory cytokines in vitro and in vivo, the results show that the CCEs significantly lowered the release of lipopolysaccharide (LPS)-induced pro-inflammatory cytokines. Additionally, the CCEs reduced LPS-induced organ damage. Real-time polymerase chain reaction analysis suggested that CCEs inhibit the LPS-induced mRNA expression of interleukin-1β and tumor necrosis factor-α. Western blot analysis indicated that the CCEs increased expression of IκB and attenuated the phosphorylation of IκB. Gas chromatography–mass spectrometry suggests that phytosterols and fatty acids are responsible for the anti-inflammatory properties of CCEs. Taken together, CCEs have the potential to be developed as an anti-inflammatory functional food. 其他題名： J. Agric. Food Chem 出版者： Washington, DC: American Chemical Society 出版日期： 2012-04-25 出處： Journal of agricultural and food chemistry, 2012-04, Vol.60 (16), p.4076-4082 資源來源： American Chemical Society Journals 版權： Copyright © 2012 American Chemical Society 版權： 2015 INIST-CNRS 識別號： ISSN: 0021-8561 識別號： ISSN: 1520-5118 識別號： EISSN: 1520-5118 識別號： DOI: 10.1021/jf2051202 識別號： PMID: 22471296 識別號： CODEN: JAFCAU
Appears in Collections:	[Center for General Education ] journal & Dissertation

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