miRTarBase 2016: Updates to the experimentally validated miRNA-target interactions database

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Title:	miRTarBase 2016: Updates to the experimentally validated miRNA-target interactions database
Authors:	吳忻怡;Chou, Chih-Hung;Chang, Nai-Wen;Shrestha, Sirjana;Hsu, Sheng-Da;Lin, Yu-Ling;Lee, Wei-Hsiang;Yang, Chi-Dung;Hong, Hsiao-Chin;Wei, Ting-Yen;Tu, Siang-Jyun;Tsai, Tzi-Ren;Ho, Shu-Yi;Jian, Ting-Yan;Wu, Hsin-Yi;Chen, Pin-Rong;Lin, Nai-Chieh;Huang, Hsin-Tzu;Yang, Tzu-Ling;Pai, Chung-Yuan;Tai, Chun-San;Chen, Wen-Liang;Huang, Chia-Yen;Liu, Chun-Chi;Weng, Shun-Long;Liao, Kuang-Wen;Hsu, Wen-Lian;Huang, Hsien-Da
Contributors:	總教學中心通識教育中心
Keywords:	Database Issue;Databases, Nucleic Acid;Disease - genetics;Gene Expression Profiling;Humans;MicroRNAs - metabolism;RNA, Messenger - chemistry;RNA, Messenger - metabolism;Sequence Analysis, RNA
Date:	2016-01-01
Issue Date:	2026-04-23 12:54:56 (UTC+8)
Publisher:	Oxford University Press;England: Oxford University Press (OUP)
Abstract:	摘要： MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which negatively regulate the gene expression at the post-transcriptional level. This study describes an update of the miRTarBase (http://miRTarBase.mbc.nctu.edu.tw/) that provides information about experimentally validated miRNA-target interactions (MTIs). The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets that were generated by 21 independent studies. The database contains 4966 articles, 7439 strongly validated MTIs (using reporter assays or western blots) and 348 007 MTIs from CLIP-seq. The number of MTIs in the miRTarBase has increased around 7-fold since the 2014 miRTarBase update. The miRNA and gene expression profiles from The Cancer Genome Atlas (TCGA) are integrated to provide an effective overview of this exponential growth in the miRNA experimental data. These improvements make the miRTarBase one of the more comprehensively annotated, experimentally validated miRNA-target interactions databases and motivate additional miRNA research efforts. 其他題名： Nucleic Acids Res 出版者： England: Oxford University Press (OUP) 出版日期： 2016-01-04 出處： Nucleic Acids Research, 2016-01, Vol.44 (D1), p.D239-247 版權： The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. 版權： The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. 2016 識別號： ISSN: 0305-1048 識別號： ISSN: 1362-4962 識別號： ISSN: 1362-4954 識別號： EISSN: 1362-4962 識別號： DOI: 10.1093/nar/gkv1258 識別號： PMID: 26590260
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