Association between history of dental amalgam fillings and risk of Parkinson's disease: A population-based retrospective cohort study in Taiwan

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Title:	Association between history of dental amalgam fillings and risk of Parkinson's disease: A population-based retrospective cohort study in Taiwan
Authors:	洪炯宗;Hsu, Yung-Chuang;Chang, Cheng-Wei;Lee, Hsin-Lin;Chuang, Chuan-Chung;Chiu, Hsien-Chung;Li, Wan-Yun;Horng, Jorng-Tzong;Fu, Earl
Contributors:	資訊電機學院資訊工程學系
Keywords:	Adult;Age;Aged;Alzheimer's disease;Case-Control Studies;Cohort analysis;Complications and side effects;Computer science;Confidence intervals;Dental Amalgam - adverse effects;Dental Amalgam - therapeutic use;Dental Amalgam - toxicity;Dental amalgams;Dental caries;Dental restorative materials;Dentistry;Diabetes;Diabetes mellitus;Epidemiology;Female;Gene expression;Head injuries;Health aspects;Health risks;Hospitals;Humans;Hyperlipidemia;Hypertension;Informatics;Kinases;Male;Medical diagnosis;Medicine and Health Sciences;Mercury - adverse effects;Mercury - therapeutic use;Metabolism;Middle Aged;Movement disorders;Neurodegenerative diseases;Older people;Online databases;Oxidative stress;Parkinson disease;Parkinson Disease, Secondary - chemically induced;Parkinson Disease, Secondary - epidemiology;Parkinson Disease, Secondary - pathology;Parkinson's disease;Patients;Physical Sciences;Population;Population studies;Population-based studies;Proportional Hazards Models;Risk;Risk Factors;Studies;Taiwan
Date:	2016-12-01
Issue Date:	2026-04-23 13:18:12 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： The impact of dental amalgam on the development of Parkinson's disease (PD) is still uncertain, although a positive association between dental amalgam and PD has been found in a few case-control studies. The patients with amalgam fillings restored between 2000 and 2008 were identified by using the National Health Insurance Research Database (NHIRD) in Taiwan. The same number of patients who had no new amalgam filling restored was matched by sex, age, and treatment date. Both cohorts were followed up from the treatment date until the date of diagnosis of PD, death, or the end of the year 2008. The individuals who received amalgam fillings had a significantly higher risk of PD afterward (adjusted hazard ratio [HR]=1.583, 95% confidence interval [CI]=1.122-2.234, p=0.0089) than those who did not. In the individuals who received amalgam fillings, being diagnosed with diabetes or hyperlipidemia demonstrated a significantly lower HR of PD occurrence than in the patients without diabetes or hyperlipidemia (HR=0.449, 95% CI=0.254-0.794, p=0.0059; HR=0.445, 95% CI=0.260-0.763, p=0.0032) after adjusting for comorbidities and Charlson-Deyo Comorbidity Index (CCI) scores. Meanwhile, hypertension increased the hazard risk of PD (HR=1.645, 95% CI=1.098-2.464, p=0.0159). The patients exposed to dental amalgam fillings were 1.583 times more likely to have PD afterward compared to their non-exposed counterparts after adjusting for comorbidities and CCI scores. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2016-12-01 出處： PloS one, 2016-12, Vol.11 (12), p.e0166552 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2016 Public Library of Science 版權： 2016 Hsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2016 Hsu et al 2016 Hsu et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0166552 識別號： PMID: 27906991
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