A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo

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題名:	A programmable high-voltage compliance neural stimulator for deep brain stimulation in vivo
作者:	龔存雄;Gong, Cihun-Siyong;Lai, Hsin-Yi;Huang, Sy-Han;Lo, Yu-Chun;Lee, Nicole;Chen, Pin-Yuan;Tu, Po-Hsun;Yang, Chia-Yen;Lin, James;Chen, You-Yin
貢獻者:	資訊電機學院電機工程學系
關鍵詞:	Animals;Biomedical engineering;Brain;Brain research;complementary metal-oxide-semiconductor (CMOS);Compliance;DBS;Deep brain stimulation;deep brain stimulation (DBS);Deep Brain Stimulation - instrumentation;Devices;Efficiency;Electrodes, Implanted;Electronic mail systems;Engineering;Equipment Design;Fines & penalties;Forelimb - physiology;high-voltage compliance neural stimulator;Male;Medical devices;Medical research;Neural Prostheses;Neurosurgery;Rats, Wistar;Semiconductors;Sensors;Somatosensory Cortex - physiology;Somatosensory Cortex - surgery;Stimulation;Stimulators;Thresholds
日期:	2015-05-28
上傳時間:	2026-04-23 13:22:30 (UTC+8)
出版者:	MDPI Multidisciplinary Digital Publishing Institute;Switzerland: MDPI AG
摘要:	摘要： Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design. 其他題名： Sensors (Basel) 出版者： Switzerland: MDPI AG 出版日期： 2015-05-28 出處： Sensors (Basel, Switzerland), 2015-05, Vol.15 (6), p.12700-12719 資源來源： Directory of Open Access Journals (DOAJ) 版權： Copyright MDPI AG 2015 版權： 2015 by the authors; licensee MDPI, Basel, Switzerland. 2015 識別號： ISSN: 1424-8220 識別號： EISSN: 1424-8220 識別號： DOI: 10.3390/s150612700 識別號： PMID: 26029954
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