Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study

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Title:	Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study
Authors:	洪炯宗;Chan, Pei-Chun;Yu, Chong-Hua;Yeh, Kuo-Wei;Horng, Jorng-Tzong;Huang, Jing-Long
Contributors:	資訊電機學院資訊工程學系
Keywords:	Adolescent;Child;Child, Preschool;Comorbidity;Female;Humans;Infant;Infant, Newborn;Infectious Disease;Lupus Erythematosus, Systemic - epidemiology;Male;Medical Education;Pediatric;Systemic lupus erythematosus;Taiwan;Taiwan - epidemiology
Date:	2016-04-01
Issue Date:	2026-04-23 13:25:03 (UTC+8)
Publisher:	Elsevier Taiwan LLC;England: Elsevier B.V
Abstract:	摘要： Systemic lupus erythematous (SLE) is a systemic and complex disease that can involve multiple organs. To clarify the risk of developing associated comorbidities after a diagnosis of SLE in children, we used the National Health Insurance Research Database (NHIRD) in Taiwan to investigate diseases experienced in these patients. This is the first nationwide population-based study of the comorbidities of pediatric SLE patients. The study was based on data from the NHIRD in Taiwan. Children were enrolled who were below the age of 18 years and whose disease corresponded to the International Classification of Disease, Ninth Revision Clinical Modification (ICD-9-CM) diagnostic code of 710.0 (SLE). The comorbidities associated with SLE were defined by the ICD-9-CM codes of diseases that presented after the SLE diagnosis. We analyzed the common diseases in SLE patients and compared the frequency of these diseases between pediatric SLE patients and the non-SLE population. From January 1, 2003 to December 31, 2008, we enrolled 904 SLE patients (774 females, 130 males). Infection (86.36%) was the most common comorbidity in pediatric SLE. Other comorbidities were musculoskeletal diseases (16.7%), cardiovascular diseases (16.37%), ocular diseases (10.73%), and renal diseases (6.75%). Children with SLE had a higher risk of heart failure, hypertension, osteoporosis, cataracts, glaucoma, dyslipidemia, seizures, encephalopathy, and malignant changes, compared to non-SLE populations. The population-based cohort demonstrated several systemic and/or chronic diseases in pediatric SLE patients in Taiwan. Children with SLE were more susceptible to these diseases, including malignancy, compared to the non-SLE population. 其他題名： J Microbiol Immunol Infect 出版者： England: Elsevier B.V 出版日期： 2016-04-01 出處： Journal of microbiology, immunology and infection, 2016-04, Vol.49 (2), p.257-263 資源來源： Elsevier ScienceDirect Journals Complete 版權： 2014 版權： Copyright © 2014. Published by Elsevier B.V. 識別號： ISSN: 1684-1182 識別號： ISSN: 1995-9133 識別號： EISSN: 1995-9133 識別號： DOI: 10.1016/j.jmii.2014.05.001 識別號： PMID: 25066707
Appears in Collections:	[Department of Computer Science and information Engineering] journal & Dissertation

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