Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population

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題名:	Association of polymorphisms in BDNF, MTHFR, and genes involved in the dopaminergic pathway with memory in a healthy Chinese population
作者:	李柏磊;Yeh, Ting-Kuang;Hu, Chung-Yi;Yeh, Ting-Chi;Lin, Pei-Jung;Wu, Chung-Hsin;Lee, Po-Lei;Chang, Chun-Yen
貢獻者:	資訊電機學院電機工程學系
關鍵詞:	Acoustic Stimulation;Adolescent;Asian Continental Ancestry Group - genetics;Auditory memory;Auditory Perception;BDNF;Biological and medical sciences;Brain-Derived Neurotrophic Factor - genetics;Cognition - physiology;Dopaminergic pathway;DRD3;Female;Foreign Countries;Fundamental and applied biological sciences. Psychology;Gene Frequency;Genetic Association Studies;Genetics;Human;Humans;Learning. Memory;Male;Memory;Memory - physiology;Methylenetetrahydrofolate Reductase (NADPH2) - genetics;Neurological Organization;Neuropsychological Tests;Polymorphism;Polymorphism, Single Nucleotide;Psychology. Psychoanalysis. Psychiatry;Psychology. Psychophysiology;Receptors, Dopamine D3 - genetics;Taiwan;Undergraduate Students;Wechsler Adult Intelligence Scale;Wechsler Memory Scale;Young Adult
日期:	2012-11-01
上傳時間:	2026-04-23 13:33:36 (UTC+8)
出版者:	Academic Press Inc.;Amsterdam: Elsevier Inc
摘要:	摘要： ► We explored the association between memory and candidate genes. ► Dopaminergic pathway genes, BDNF, and MTHFR genes were selected. ► BDNF Met66Val polymorphism was associated with auditory delayed memory. ► DRD3 Ser9Gly polymorphism was associated with auditory recognition memory. The contribution of genetic factors to the memory is widely acknowledged. Research suggests that these factors include genes involved in the dopaminergic pathway, as well as the genes for brain-derived neurotrophic factor (BDNF) and methylenetetrahydrofolate reductase (MTHFR). The activity of the products of these genes is affected by single nucleotide polymorphisms (SNPs) within the genes. This study investigates the association between memory and SNPs in genes involved in the dopaminergic pathway, as well as in the BDNF and MTHFR genes, in a sample of healthy individuals. The sample includes 134 Taiwanese undergraduate volunteers of similar cognitive ability. The Chinese versions of the Wechsler Memory Scale (WMS-III) and Wechsler Adult Intelligence Scale (WAIS-III) were employed. Our findings indicate that the BDNF Met66Val polymorphism and dopamine receptor D3 (DRD3) Ser9Gly polymorphism are associated significantly with long-term auditory memory. Further analysis detects no significant associations in the other polymorphisms and indices. Future replicated studies with larger sample sizes, and studies that consider different ethnic groups, are encouraged. 其他題名： Brain Cogn 出版者： Amsterdam: Elsevier Inc 出版日期： 2012-11-01 出處： Brain and cognition, 2012-11, Vol.80 (2), p.282-289 資源來源： Education Resources Information Center (ERIC) 版權： 2012 Elsevier Inc. 版權： 2015 INIST-CNRS 版權： Copyright © 2012 Elsevier Inc. All rights reserved. 識別號： ISSN: 0278-2626 識別號： ISSN: 1090-2147 識別號： EISSN: 1090-2147 識別號： DOI: 10.1016/j.bandc.2012.06.005 識別號： PMID: 22940753 識別號： CODEN: BRCOEI
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