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| 題名: | Automated segmentation and quantification of white matter hyperintensities in acute ischemic stroke patients with cerebral infarction |
| 作者: | 蔡章仁;Tsai, Jang-Zern;Peng, Syu-Jyun;Chen, Yu-Wei;Wang, Kuo-Wei;Li, Chen-Hua;Wang, Jing-Yi;Chen, Chi-Jen;Lin, Huey-Juan;Smith, Eric Edward;Wu, Hsiao-Kuang;Sung, Sheng-Feng;Yeh, Poh-Shiow;Hsin, Yue-Loong |
| 貢獻者: | 資訊電機學院電機工程學系 |
| 關鍵詞: | Aged;Aged, 80 and over;Algorithms;Brain research;Cerebral infarction;Cerebral Infarction - diagnosis;Cerebral Infarction - pathology;Cognitive ability;Computer and Information Sciences;Computer engineering;Computer science;Delineation;Edema;Electrical engineering;Engineering and Technology;Female;Hemispheres;Hemorrhage;Hospitals;Human bias;Humans;Image processing;Image Processing, Computer-Assisted;Image segmentation;Infarction;Ischemia;Magnetic resonance;Magnetic Resonance Imaging;Male;Medicine and Health Sciences;Methods;Middle Aged;Morphology;Multiple sclerosis;Neurology;NMR;Nuclear magnetic resonance;Patients;Reproducibility of Results;Segmentation;Stroke;Substantia alba;Subtraction;White Matter - pathology;Workflow |
| 日期: | 2014-08-15 |
| 上傳時間: | 2026-04-23 13:34:49 (UTC+8) |
| 出版者: | Public Library of Science;United States: Public Library of Science |
| 摘要: | 摘要： White matter hyperintensities (WMHs) of presumed vascular origin are common in ageing population, especially in patients with acute cerebral infarction and the volume has been reported to be associated with mental impairment and the risk of hemorrhage from antithrombotic agents. WMHs delineation can be computerized to minimize human bias. However, the presence of cerebral infarcts greatly degrades the accuracy of WMHs detection and thus limits the application of computerized delineation to patients with acute cerebral infarction. We propose a computer-assisted segmentation method to depict WMHs in the presence of cerebral infarcts in combined T1-weighted, fluid attenuation inversion recovery, and diffusion-weighted magnetic resonance imaging (MRI). The proposed method detects WMHs by empirical threshold and atlas information, with subtraction of white matter voxels affected by acute infarction. The method was derived using MRI from 25 hemispheres with WMHs only and 13 hemispheres with both WMHs and cerebral infarcts. Similarity index (SI) and correlation were utilized to assess the agreement between the new automated method and a gold standard visually guided semi-automated method done by an expert rater. The proposed WMHs segmentation approach produced average SI, sensitivity and specificity of 83.142±11.742, 84.154±16.086 and 99.988±0.029% with WMHs only and of 68.826±14.036, 74.381±18.473 and 99.956±0.054% with both WMHs and cerebral infarcts in the derivation cohort. The performance of the proposed method with an external validation cohort was also highly consistent with that of the experienced rater.
其他題名： PLoS One
出版者： United States: Public Library of Science
出版日期： 2014-08-15
出處： PloS one, 2014-08, Vol.9 (8), p.e104011
資源來源： DOAJ (selected full-text)
版權： 2014 Tsai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
版權： 2014 Tsai et al 2014 Tsai et al
識別號： ISSN: 1932-6203
識別號： EISSN: 1932-6203
識別號： DOI: 10.1371/journal.pone.0104011
識別號： PMID: 25127120 |
| 顯示於類別: | [電機工程學系] 期刊論文
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