Effects of statins on incident dementia in patients with type 2 DM: A population-based retrospective cohort study in Taiwan

NCUIR > College of Electrical Engineering & Computer Science > Department of Computer Science and information Engineering > journal & Dissertation > Item 987654321/106658

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/106658

Title:	Effects of statins on incident dementia in patients with type 2 DM: A population-based retrospective cohort study in Taiwan
Authors:	洪炯宗;Chen, Jui-Ming;Chang, Cheng-Wei;Chang, Tzu-Hao;Hsu, Chi-Chang;Horng, Jorng-Tzong;Sheu, Wayne H-H
Contributors:	資訊電機學院資訊工程學系
Keywords:	Aged;Aged, 80 and over;Alzheimer Disease - complications;Alzheimer Disease - drug therapy;Alzheimer's disease;Ambulatory care;Analysis;Atorvastatin;Care and treatment;Cognitive ability;Cohort analysis;Comorbidity;Computer science;Dementia;Dementia - complications;Dementia - drug therapy;Dementia disorders;Demographics;Demography;Development and progression;Diabetes;Diabetes mellitus;Diabetes Mellitus, Type 2 - complications;Diabetes Mellitus, Type 2 - drug therapy;Drugs;Endocrinology;Female;Hazards;Health insurance;Health risk assessment;Health risks;Hospitals;Humans;Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use;Hypoglycemic agents;Informatics;Kaplan-Meier Estimate;Male;Medical diagnosis;Medical research;Medicine;Metabolism;Middle Aged;National health insurance;Neurodegenerative diseases;Patients;Population;Population studies;Population-based studies;Regression analysis;Regression models;Retrospective Studies;Risk Factors;Simvastatin;Statins;Studies;Substance abuse treatment;Taiwan;Type 2 diabetes
Date:	2014-02-10
Issue Date:	2026-04-23 13:35:11 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： Patients with Type 2 diabetes (T2DM) are prone to develop dementia. Results from a recent study indicated that statin users had lower chance of developing incident dementia. However there is little information on the potential benefits of statin use on dementia in patients with T2DM cohort. A population-based retrospective study using a nationwide cohort of National Health Insurance Research Database in Taiwan was performed. T2DM cohort with regular use of statins was followed up to 8 years. Multivariate cox-proportional hazards regression model was used to estimate the association between statin use and incidence of dementia including Alzheimer's disease and non-Alzheimer dementia after adjusting for several potential confounders. Among 28,321 patients diagnosed with T2DM age above 50 and without history of dementia before 2000/1/1, 15,770 patients who had never used statin and 2,400 patients who regularly used statin drugs were enrolled. After adjusting for age group, gender, CCI (Charlson-Deyo comorbidity index) group, stroke types and anti-diabetic drugs, regular statin use was associated with a decreased risk of developing incident Alzheimer's disease dementia (adjusted HR: 0.48, 95% CI 0.30 - 0.76, p<0.001), but not in non-Alzheimer dementia (adjusted HR: 1.07, 95% CI 0.54-2.12 p = 0.844) in patients with T2DM. Further analysis showed significant protective effects of the use of atorvastatin and simvastatin. Regular use of statins might decrease the risk of developing Alzheimer's disease in patients with T2DM while no benefit was observed in non-Alzheimer dementia. Among statins, both atorvastatin and simvastatin showed significant benefits. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2014-02-10 出處： PloS one, 2014-02, Vol.9 (2), p.e88434 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2014 Public Library of Science 版權： 2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2014 Chen et al 2014 Chen et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0088434 識別號： PMID: 24520388
Appears in Collections:	[Department of Computer Science and information Engineering] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	13	View/Open

社群 sharing

Loading...