Change in the cortical complexity of spinocerebellar ataxia type 3 appears earlier than clinical symptoms

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Title:	Change in the cortical complexity of spinocerebellar ataxia type 3 appears earlier than clinical symptoms
Authors:	徐國鎧;Wang, Tzu-Yun;Jao, Chii-Wen;Soong, Bing-Wen;Wu, Hsiu-Mei;Shyu, Kuo-Kai;Wang, Po-Shan;Wu, Yu-Te
Contributors:	資訊電機學院電機工程學系
Keywords:	Archives & records;Ataxia;Atrophy;Brain research;Case-Control Studies;Cerebellar Ataxia - pathology;Cerebellum;Cerebral cortex;Cerebral Cortex - pathology;Cognitive ability;Cognitive impairment;Complexity;Degeneration;Delirium;EEG;Electroencephalography;Female;Humans;Machado-Joseph disease;Machado-Joseph Disease - pathology;Magnetic resonance;Magnetic resonance imaging;Magnetic Resonance Imaging - methods;Male;Medical imaging;Middle Aged;Neuroimaging;Neurology;Neurosciences;Patients;Schizophrenia;Spinocerebellar ataxias;Studies
Date:	2015-04-21
Issue Date:	2026-04-23 13:38:36 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science
Abstract:	摘要： Patients with spinocerebellar ataxia type 3 (SCA3) have exhibited cerebral cortical involvement and various mental deficits in previous studies. Clinically, conventional measurements, such as the Mini-Mental State Examination (MMSE) and electroencephalography (EEG), are insensitive to cerebral cortical involvement and mental deficits associated with SCA3, particularly at the early stage of the disease. We applied a three-dimensional fractal dimension (3D-FD) method, which can be used to quantify the shape complexity of cortical folding, in assessing cortical degeneration. We evaluated 48 genetically confirmed SCA3 patients by employing clinical scales and magnetic resonance imaging and using 50 healthy participants as a control group. According to the Scale for the Assessment and Rating of Ataxia (SARA), the SCA3 patients were diagnosed with cortical dysfunction in the cerebellar cortex; however, no significant difference in the cerebral cortex was observed according to the patients' MMSE ratings. Using the 3D-FD method, we determined that cortical involvement was more extensive than involvement of traditional olivopontocerebellar regions and the corticocerebellar system. Moreover, the significant correlation between decreased 3D-FD values and disease duration may indicate atrophy of the cerebellar cortex and cerebral cortex in SCA3 patients. The change of the cerebral complexity in the SCA3 patients can be detected throughout the disease duration, especially it becomes substantial at the late stage of the disease. Furthermore, we determined that atrophy of the cerebral cortex may occur earlier than changes in MMSE scores and EEG signals. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2015-04-21 出處： PloS one, 2015-04, Vol.10 (4), p.e0118828 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2015 Public Library of Science 版權： 2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2015 Wang et al 2015 Wang et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0118828 識別號： PMID: 25897782
Appears in Collections:	[Department of Electrical Engineering] journal & Dissertation

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