Expression profiles of loneliness-associated genes for survival prediction in cancer patients

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Title:	Expression profiles of loneliness-associated genes for survival prediction in cancer patients
Authors:	蘇木春;You, Liang-Fu;Yeh, Jia-Rong;Su, Mu-Chun
Contributors:	資訊電機學院資訊工程學系
Keywords:	Bone Neoplasms - genetics;Bone Neoplasms - mortality;Bone Neoplasms - psychology;Female;Humans;Kaplan-Meier Estimate;Leukemia - genetics;Leukemia - mortality;Leukemia - psychology;Loneliness - psychology;Lung Neoplasms - genetics;Lung Neoplasms - mortality;Lung Neoplasms - psychology;Lymphoma - genetics;Lymphoma - mortality;Lymphoma - psychology;Male;Middle Aged;Neoplasms - genetics;Neoplasms - mortality;Neoplasms - psychology;Ovarian Neoplasms - genetics;Ovarian Neoplasms - mortality;Ovarian Neoplasms - psychology;Proportional Hazards Models;Psychiatric Status Rating Scales;Survival Rate;Transcriptome
Date:	2014-01-01
Issue Date:	2026-04-23 13:41:40 (UTC+8)
Publisher:	Asian Pacific Organization for Cancer Prevention;Thailand
Abstract:	摘要： Influence of loneliness on human survival has been established epidemiologically, but genomic research remains undeveloped. We identified 34 loneliness-associated genes which were statistically significant for high- lonely and low-lonely individuals. With the univariate Cox proportional hazards regression model, we obtained corresponding regression coefficients for loneliness-associated genes fo individual cancer patients. Furthermore, risk scores could be generated with the combination of gene expression level multiplied by corresponding regression coefficients of loneliness-associated genes. We verified that high-risk score cancer patients had shorter mean survival time than their low-risk score counterparts. Then we validated the loneliness-associated gene signature in three independent brain cancer cohorts with Kaplan-Meier survival curves (n=77, 85 and 191), significantly separable by log-rank test with hazard ratios (HR) >1 and p-values <0.0001 (HR=2.94, 3.82, and 1.78). Moreover, we validated the loneliness-associated gene signature in bone cancer (HR=5.10, p-value=4.69e-3), lung cancer (HR=2.86, p-value=4.71e-5), ovarian cancer (HR=1.97, p-value=3.11e-5), and leukemia (HR=2.06, p-value=1.79e-4) cohorts. The last lymphoma cohort proved to have an HR=3.50, p-value=1.15e-7. Loneliness- associated genes had good survival prediction for cancer patients, especially bone cancer patients. Our study provided the first indication that expression of loneliness-associated genes are related to survival time of cancer patients. 其他題名： Asian Pac J Cancer Prev 出版者： Thailand 出版日期： 2014-01-01 出處： Asian Pacific journal of cancer prevention : APJCP, 2014-01, Vol.15 (1), p.185-190 識別號： ISSN: 1513-7368 識別號： ISSN: 2476-762X 識別號： EISSN: 2476-762X 識別號： DOI: 10.7314/APJCP.2014.15.1.185 識別號： PMID: 24528024
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