Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer's Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan

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Title:	Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer's Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan
Authors:	洪炯宗;Chen, Jui-Ming;Hsu, Chi-Chang;Horng, Jorng-Tzong;Chang, Cheng-Wei
Contributors:	資訊電機學院資訊工程學系
Keywords:	Aged;Aged, 80 and over;Alzheimer Disease - epidemiology;Alzheimer Disease - etiology;Alzheimer Disease - prevention & control;Alzheimer's disease;Aspirin;Aspirin - administration & dosage;Aspirin - therapeutic use;Chronic illnesses;Codes;Cohort analysis;Comorbidity;Databases, Factual;Dementia;Development and progression;Diabetes;Diabetes Mellitus, Type 2 - complications;Disease;Dose-Response Relationship, Drug;Drug dosages;Female;Health insurance;Health risk assessment;Humans;Incidence;Male;Medical research;Middle Aged;Patients;Population;Prescription drugs;Protective Agents - administration & dosage;Protective Agents - therapeutic use;Retrospective Studies;Risk;Risk factors;Stroke;Studies;Taiwan - epidemiology;Type 2 diabetes
Date:	2016-01-01
Issue Date:	2026-04-23 13:52:19 (UTC+8)
Publisher:	Hindawi Limited;Cairo, Egypt: Hindawi Publishing Corporation
Abstract:	摘要： Background. Type 2 diabetes mellitus patients are known to have higher risk of developing dementia while aspirin use has been shown to prevent incident dementia. This study was conducted to evaluate the potential benefits of aspirin use on dementia in patients with type 2 diabetes mellitus and identify the appropriate dosage of aspirin that provides the most benefit. Method. A Taiwan nationwide, population-based retrospective 8-year study was employed to analyze the association between the use of aspirin and incidence of dementia including Alzheimer’s disease and non-Alzheimer’s dementia using multivariate Cox-proportional hazards regression model and adjusting for several potential confounders. Results. Regular aspirin use in mean daily dosage of within 40 mg was associated with a decreased risk of developing incident Alzheimer’s dementia in patients with type 2 diabetes mellitus (adjusted HR of 0.51 with 95% CI of 0.27–0.97, p value 0.041). Conclusion. A mean daily dosage of aspirin use within 40 mg might decrease the risk of developing Alzheimer’s disease in patients with type 2 diabetes mellitus. 其他題名： J Diabetes Res 出版者： Cairo, Egypt: Hindawi Publishing Corporation 出版日期： 2016-01-01 出處： Journal of Diabetes Research, 2016-01, Vol.2016 (2016), p.1-8 資源來源： Healthcare Administration Database 版權： Copyright © 2016 Cheng-Wei Chang et al. 版權： COPYRIGHT 2016 John Wiley & Sons, Inc. 版權： COPYRIGHT 2016 Hindawi Limited 版權： Copyright © 2016 Cheng-Wei Chang et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： Copyright © 2016 Cheng-Wei Chang et al. 2016 識別號： ISSN: 2314-6745 識別號： ISSN: 2314-6753 識別號： EISSN: 2314-6753 識別號： DOI: 10.1155/2016/9027484 識別號： PMID: 27868071
Appears in Collections:	[Department of Computer Science and information Engineering] journal & Dissertation

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