Population-based cohort study on the risk of malignancy in East Asian children with Juvenile idiopathic arthritis

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Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/107128

Title:	Population-based cohort study on the risk of malignancy in East Asian children with Juvenile idiopathic arthritis
Authors:	洪炯宗;Kok, Victor C;Horng, Jorng-Tzong;Huang, Jing-Long;Yeh, Kuo-Wei;Gau, Jia-Jing;Chang, Cheng-Wei;Zhuang, Lai-Zhen
Contributors:	資訊電機學院資訊工程學系
Keywords:	Acquisitions & mergers;Adolescent;Age;Arthritis;Arthritis, Juvenile - drug therapy;Arthritis, Juvenile - epidemiology;Biological Products - adverse effects;Biological Products - therapeutic use;Biomedical and Life Sciences;Biomedicine;Cancer;Cancer Research;Cancer therapies;Child;Child, Preschool;Codes;Disease;Epidemiology;Far East - epidemiology;Female;Health insurance;Health Promotion and Disease Prevention;Health risk assessment;Hospitals;Humans;Infant;Infant, Newborn;Information management;Male;Medical records;Medical research;Medicine/Public Health;Methotrexate - adverse effects;Methotrexate - therapeutic use;Neoplasms - chemically induced;Neoplasms - epidemiology;Oncology;Population;prevention and public health;Research Article;Retrospective Studies;Rheumatology;Risk Assessment;Risk Factors;Studies;Surgical Oncology;TNF inhibitors;Tumor Necrosis Factor-alpha - antagonists & inhibitors
Date:	2014-08-29
Issue Date:	2026-04-23 13:57:17 (UTC+8)
Publisher:	BioMed Central Ltd.;London: BioMed Central
Abstract:	摘要： Background To investigate the association and magnitude of risk between JIA, its associated treatment and cancer development in Taiwanese children. Methods Nationwide population-based 1:4 age- and gender-matched retrospective cohort study was designed using the National Health Insurance Research Database of Taiwan. A cohort of 2,892 children <16 years old with JIA was formed as well as a non-JIA cohort of 11,568 in year 2003 to 2005. They were followed up till a diagnosis of malignancy or up to 8 years until 2010. Relative risk (RR), incidence rate ratio (IRR), and adjusted hazard ratio (aHR) of developing malignancy were calculated. Results The female to male ratio was 0.79:1. There were 3 cases of incident cancer in the “MTX use, biologics-naïve” group, only 1 in the anti-TNF biologics-containing group and 29 in the “both MTX- and biologics-naïve” group, in comparison, there were 50 cases of cancer in the non-JIA comparator group. During a 16114.16 patient-years follow-up, the RR and IRR for developing a malignancy in both methotrexate- and anti-tumor necrosis factor (TNF) biologics-naïve JIA children were 2.75 (95% confidence interval, 1.75 – 4.32) and 3.21 (2.01 – 5.05), respectively. For leukemia, the IRR was 7.38 (2.50 – 22.75); lymphoma, 8.30 (1.23 – 69.79); and soft tissue sarcoma, 11.07 (0.84 – 326.4). The IRR of other cancers was 2.08 (1.11 – 3.71). The aHR on cancer risk was 3.14 (1.98 – 4.98) in methotrexate- and biologics-naïve group. There were no statistically significant increased risk in JIA patients treated with methotrexate and/or anti-TNF biologics. Conclusions Compared with children without JIA, children with JIA have 3-fold increase of risk on malignancy in East Asia. Seemingly neither methotrexate nor anti-TNF biologics increases the risk further. 其他題名： BMC Cancer 出版者： London: BioMed Central 出版日期： 2014-08-29 出處： BMC cancer, 2014-08, Vol.14 (1), p.634, Article 634 資源來源： Publicly Available Content Database 版權： Kok et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. 版權： 2014 Kok et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. 版權： Kok et al.; licensee BioMed Central Ltd. 2014 識別號： ISSN: 1471-2407 識別號： EISSN: 1471-2407 識別號： DOI: 10.1186/1471-2407-14-634 識別號： PMID: 25174953
Appears in Collections:	[Department of Computer Science and information Engineering] journal & Dissertation

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