Risk of Autoimmune Disease in Adults with Chronic Insomnia Requiring Sleep-Inducing Pills: A Population-Based Longitudinal Study

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Title:	Risk of Autoimmune Disease in Adults with Chronic Insomnia Requiring Sleep-Inducing Pills: A Population-Based Longitudinal Study
Authors:	洪炯宗;Kok, Victor C.;Horng, Jorng-Tzong;Hung, Guo-Dung;Xu, Jia-Li;Hung, Tzu-Wei;Chen, Yu-Ching;Chen, Chien-Lung
Contributors:	資訊電機學院資訊工程學系
Keywords:	Adult;Adults;Aged;Aged, 80 and over;Alcoholic beverages;Autoimmune diseases;Autoimmune Diseases - chemically induced;Autoimmune Diseases - diagnosis;Autoimmune Diseases - epidemiology;Chronic Disease;Confidence intervals;Correlation analysis;Female;Follow-Up Studies;Health risks;Humans;Hypnotics and Sedatives - adverse effects;Hypnotics and Sedatives - therapeutic use;Insomnia;Insurance;Internal Medicine;Longitudinal Studies;Male;Medicine;Medicine & Public Health;Middle Aged;Original Research;Pneumoviridae;Population studies;Population Surveillance - methods;Population-based studies;Risk analysis;Risk Factors;Sensitivity analysis;Sjogren's syndrome;Sleep;Sleep disorders;Sleep Initiation and Maintenance Disorders - diagnosis;Sleep Initiation and Maintenance Disorders - drug therapy;Sleep Initiation and Maintenance Disorders - epidemiology;Smoking;Taiwan - epidemiology;Time lag;Urbanization;Young Adult
Date:	2016-09-01
Issue Date:	2026-04-23 14:00:03 (UTC+8)
Publisher:	New York: Springer US
Abstract:	摘要： ABSTRACT BACKGROUND Recent studies indicate that chronic insomnia is associated with the development of certain somatic diseases. Whether it would be associated with the development of an autoimmune disease (AID) was unknown. OBJECTIVE We aimed to examine the association and quantify the magnitude of risk for AID in individuals suffering from chronic insomnia requiring sleep-inducing pills. DESIGN This was a population-based, nationwide longitudinal study. PARTICIPANTS Using a claims data set containing 1 million randomly sampled, insured subjects derived from the National Health Insurance Research Database, we assembled a chronic insomnia group and a 1:3 propensity score–matched comparison group (CP), which were balanced in terms of sex, age, insurance premium, urbanization, alcohol use disorder, smoking-related diagnoses, and morbid obesity. MAIN MEASURES Person-time data with incidence rate, adjusted hazard ratios (aHR) by the Cox model, AID-free survival functions compared with the log-rank test, and a sensitivity analysis on the time lag effect were presented. Incident AID within the first year of follow-up were excluded. The error rate was controlled using the Benjamini–Hochberg procedure. KEY RESULTS With 39,550 and 129,914 person-years’ follow-up for the chronic insomnia and CP groups ( n = 5,736 and 17,208), respectively, we found an increased risk for subsequent AID, representing a 70 % increase in the aHR (1.7; 95 % confidence interval [CI], 1.5–1.9, p < 0.0001). A positive association between chronic insomnia and primary Sjögren’s syndrome (pSS) was observed (aHR, 1.3; 95 % CI, 1.1–1.6). Sensitivity analysis disclosed that AID risk was even stronger after 5 years of follow-up (aHR, 2.0; 95 % CI, 1.7–2.4). CONCLUSION Chronic insomnia requiring sleep-inducing pills may be associated with a 70 % increased risk for future AID, particularly pSS. 其他題名： J GEN INTERN MED 其他題名： J Gen Intern Med 出版者： New York: Springer US 出版日期： 2016-09-01 出處： Journal of general internal medicine : JGIM, 2016-09, Vol.31 (9), p.1019-1026 資源來源： Healthcare Administration Database 版權： Society of General Internal Medicine 2016 版權： Journal of General Internal Medicine is a copyright of Springer, (2016). All Rights Reserved. 識別號： ISSN: 0884-8734 識別號： ISSN: 1525-1497 識別號： EISSN: 1525-1497 識別號： DOI: 10.1007/s11606-016-3717-z 識別號： PMID: 27130621
Appears in Collections:	[Department of Computer Science and information Engineering] journal & Dissertation

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