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| 題名: | Risk of tuberculosis in children with juvenile idiopathic arthritis: A nationwide population-based study in Taiwan |
| 作者: | 洪炯宗;Hsin, Yi-Chen;Zhuang, Lai-Zhen;Yeh, Kuo-Wei;Chang, Cheng-Wei;Horng, Jorng-Tzong;Huang, Jing-Long |
| 貢獻者: | 資訊電機學院資訊工程學系 |
| 關鍵詞: | Adolescent;Age;Antirheumatic Agents - therapeutic use;Arthritis;Arthritis, Juvenile - complications;Arthritis, Juvenile - drug therapy;Arthritis, Juvenile - epidemiology;Arthritis, Juvenile - immunology;Case-Control Studies;Child;Child, Preschool;Children;Codes;Computer science;Data processing;Databases, Factual;Development and progression;Etanercept - therapeutic use;Female;Gender;Hospitals;Humans;Immunology;Incidence;Infant;Infections;Infliximab - therapeutic use;Inhibitors;Male;Methotrexate;Methotrexate - therapeutic use;National health insurance;Nonsteroidal anti-inflammatory drugs;Online databases;Patients;Pediatrics;Pharmacy;Population;Population studies;Population-based studies;Proportional Hazards Models;Quality of life;Regression analysis;Regression models;Rheumatoid arthritis;Rheumatology;Risk;Studies;Taiwan - epidemiology;TNF inhibitors;Tuberculosis;Tuberculosis, Pulmonary - complications;Tuberculosis, Pulmonary - drug therapy;Tuberculosis, Pulmonary - epidemiology;Tuberculosis, Pulmonary - immunology;Tumor necrosis factor;Tumor Necrosis Factor-alpha - antagonists & inhibitors;Tumor necrosis factor-TNF |
| 日期: | 2015-06-05 |
| 上傳時間: | 2026-04-23 14:00:08 (UTC+8) |
| 出版者: | Public Library of Science;United States: Public Library of Science |
| 摘要: | 摘要： We aimed to determine the risk of tuberculosis in children with juvenile idiopathic arthritis (JIA) in Taiwan. We used the Taiwan National Health Insurance Research Database (NHIRD) to conduct a nested case-control study. We identified a JIA cohort and matched each JIA child with non-JIA children for comparison. Methotrexate (MTX), tumor necrosis factor (TNF) inhibitor administration, and new tuberculosis cases were determined during our study period. To compare tuberculosis (TB) risk among our study groups, Cox proportional regression models were used to determine adjusted hazard ratios (aHRs). We identified 1495 children with JIA and 11592 non-JIA children. Majority (68.7%) children with JIA had not received MTX or TNF inhibitors; 23.9% used MTX without TNF inhibitors, and 7.4% received TNF inhibitors, irrespective of MTX administration. In total, 43 children developed tuberculosis. The overall tuberculosis infection rate for children with JIA was two times higher than that for non-JIA children. Compared with non-JIA children, children with JIA who used MTX without TNF inhibitors revealed a significantly increased of tuberculosis infection rate (aHR = 4.67; 95% CI: 1.65-13.17; P = 0.004). Children with JIA who either received TNF inhibitors or never used MTX and TNF inhibitors revealed a tuberculosis infection rate comparable to that of non-JIA children. Analysis of nationwide data of Taiwan suggested that children with JIA were at higher risk of tuberculosis compared with those without JIA.
其他題名： PLoS One
出版者： United States: Public Library of Science
出版日期： 2015-06-05
出處： PloS one, 2015-06, Vol.10 (6), p.e0128768
資源來源： Agricultural & Environmental Science Collection
版權： COPYRIGHT 2015 Public Library of Science
版權： 2015 Hsin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
版權： 2015 Hsin et al 2015 Hsin et al
識別號： ISSN: 1932-6203
識別號： EISSN: 1932-6203
識別號： DOI: 10.1371/journal.pone.0128768
識別號： PMID: 26047099 |
| 顯示於類別: | [資訊工程學系] 期刊論文
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