Anatomical and electrophysiological manifestations in a patient with congenital corpus callosum agenesis

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題名:	Anatomical and electrophysiological manifestations in a patient with congenital corpus callosum agenesis
作者:	段正仁;Hsu, Yi-Ting;Duann, Jeng-Ren;Chen, Chun-Ming;Yang, Yu-Wan;Tsai, Chon-Haw;Lu, Ming-Kuei
貢獻者:	生醫理工學院認知神經科學研究所
關鍵詞:	Adult;Agenesis of Corpus Callosum - pathology;Agenesis of Corpus Callosum - physiopathology;Anisotropy;Biomedical and Life Sciences;Biomedicine;Brain Mapping;Brief Communication;Diffusion Tensor Imaging;Evoked Potentials, Motor - physiology;Female;Functional Laterality;Humans;Image Processing, Computer-Assisted;Male;Movement;Neural Inhibition - physiology;Neurology;Neurosciences;Psychiatry;Transcranial Magnetic Stimulation
日期:	2013-01-01
上傳時間:	2026-04-23 14:20:16 (UTC+8)
出版者:	Boston: Springer US
摘要:	摘要： The corpus callosum is the major brain structure responsible for the transferring of information between the two hemispheres. In congenital agenesis of the corpus callosum (ACC), an alternative functional connection might exist between the hemispheres; however, this has yet to be demonstrated. The present study evaluated a 27-year-old man with ACC but no detectable motor function deficits using diffusion tensor imaging (DTI), movement-related cortical potential (MRCP), and interhemispheric inhibition (IHI). The MRCP was analyzed at the electrodes of C3, FCZ, and C4. IHI was measured using paired transcranial magnetic stimulation over the hand area of the primary motor cortex at both hemispheres. Data of the patient were compared with those of an age-matched healthy control group ( n = 8, mean age: 27.6 ± 2.5 years). DTI showed absence of the callosal fibers and the presence of enhanced transcommissural fibers in the ACC patient. The mean fractional anisotropy of the transcommissural fibers revealed a significant difference between the patient and the control group (0.62 vs. 0.43, p < 0.01). The MRCP and IHI, supposed to be highly relevant to the transcallosal pathway, were present in the patient though they occurred to a relatively low degree compared to the control group. Findings suggest that in the ACC patient, the abnormal transcommissural fibers might be functional and serve as an alternative pathway connecting the bilateral hemispheres. 其他題名： Brain Topogr 出版者： Boston: Springer US 出版日期： 2013-01 出處： Brain topography, 2013-01, Vol.26 (1), p.171-176 版權： Springer Science+Business Media, LLC 2012 版權： Springer Science+Business Media New York 2013 識別號： ISSN: 0896-0267 識別號： ISSN: 1573-6792 識別號： EISSN: 1573-6792 識別號： DOI: 10.1007/s10548-012-0247-9 識別號： PMID: 22914988 識別號： CODEN: BRTOEZ
顯示於類別:	[認知與神經科學研究所 ] 期刊論文

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