Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

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题名:	Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography
作者:	龔存雄;Tsai, Meng-Tsan;Chang, Feng-Yu;Lee, Cheng-Kuang;Gong, Cihun-Siyong Alex;Lin, Yu-Xiang;Lee, Jiann-Der;Yang, Chih-Hsun;Liu, Hao-Li
贡献者:	資訊電機學院電機工程學系
日期:	2014-06-01
上传时间:	2026-04-23 14:20:46 (UTC+8)
出版者:	The Optical Society;United States: Optical Society of America
摘要:	摘要： Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of microbubbles were investigated and quantitatively compared. Additionally, 2D and 3D speckle-variance images were used for quantitative observation of blood leakage from vessels due to the permeability enhancement caused by FUS, which could be an indicator that can be used to determine the influence of FUS power exposure. In conclusion, SVOCT can be a useful tool for monitoring FUS treatment in real time, facilitating the dynamic observation of temporal effects and helping to determine the optimal FUS power. 其他題名： Biomed Opt Express 出版者： United States: Optical Society of America 出版日期： 2014-07-01 出處： Biomedical optics express, 2014-07, Vol.5 (7), p.2009-2022 資源來源： Optica Publishing Group Journals 版權： 2014 Optical Society of America 2014 Optical Society of America 識別號： ISSN: 2156-7085 識別號： EISSN: 2156-7085 識別號： DOI: 10.1364/BOE.5.002009 識別號： PMID: 25071945
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