Cognition-Modulated Frontal Activity in Prediction and Augmentation of Antidepressant Efficacy: A Randomized Controlled Pilot Study

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題名:	Cognition-Modulated Frontal Activity in Prediction and Augmentation of Antidepressant Efficacy: A Randomized Controlled Pilot Study
作者:	阮啓弘;Li, Cheng-Ta;Hsieh, Jen-Chuen;Huang, Hsiang-Hsuan;Chen, Mu-Hong;Juan, Chi-Hung;Tu, Pei-Chi;Lee, Ying-Chiao;Wang, Shyh-Jen;Cheng, Chih-Ming;Su, Tung-Ping
貢獻者:	生醫理工學院認知神經科學研究所
關鍵詞:	Adult;Antidepressive Agents;Antidepressive Agents - therapeutic use;Cognition;Cognition - drug effects;Depression;Depression - drug therapy;Depressive Disorder, Major;Depressive Disorder, Major - diagnosis;Depressive Disorder, Major - drug therapy;Female;Gyrus Cinguli;Gyrus Cinguli - drug effects;Gyrus Cinguli - physiopathology;Humans;Male;Middle Aged;Pilot Projects;Prefrontal Cortex;Prefrontal Cortex - drug effects;Prefrontal Cortex - physiopathology;Treatment Outcome
日期:	2016-01-01
上傳時間:	2026-04-23 14:22:07 (UTC+8)
出版者:	United States: Oxford University Press (OUP)
摘要:	摘要： Higher rostral anterior cingulate cortex (rACC) activity correlated with frontal theta power (frontalθ) is associated with better antidepressant responses. The antidepressant efficacy of repetitive transcranial magnetic stimulation (rTMS) varied widely; however, the effects of TMS might be modulated by manipulating the pretreatment neural states. Therefore, we conducted a pilot study to investigate whether manipulated frontalθ before rTMS treatment could predict and augment antidepressant responses. A computerized rACC-engaging cognitive task (RECT) was exploited continuously for 10 min to patients with major depressive disorder. In total, 36 patients were randomized to 3 groups (Group-A: RECT[active] + rTMS[active]; Group-B: RECT[sham] + rTMS[active]; Group-C: RECT[active] + rTMS[sham]). Frontalθ and whole-brain glucose uptakes were assessed. We found that the RECT-modulated increases in frontalθ correlated well with rACC glucose uptakes. The treatment responders demonstrated a significant increase in frontalθ after RECT. Post-RECT frontalθ had good sensitivity/specificity in predicting antidepressant responses to rTMS. Group-A had more reduction in total depression scores, had more responders, and was more likely to achieve remission than other groups (Group-A [41.6%] > Group-B [16.6%] > Group-C [0%], P < 0.05). A significant enhancement in the post-1st-rTMS frontalθ was observed in Group-A responders but not in Group-B responders, supporting the argument that RECT-modulated rTMS augmented rTMS efficacy. In conclusion, this study suggests that manipulating pre-rTMS neural activity could predict and augment antidepressant effects to rTMS treatment. 其他題名： Cereb Cortex 出版者： United States: Oxford University Press (OUP) 出版日期： 2016 出處： Cerebral Cortex, 2016, Vol.26 (1), p.202-210 版權： The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissionsoup.com. 識別號： ISSN: 1047-3211 識別號： ISSN: 1460-2199 識別號： EISSN: 1460-2199 識別號： DOI: 10.1093/cercor/bhu191 識別號： PMID: 25165064
顯示於類別:	[認知與神經科學研究所 ] 期刊論文

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