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| 題名: | Different forms of prefrontal theta burst stimulation for executive function of medication- resistant depression: Evidence from a randomized sham-controlled study |
| 作者: | 阮啓弘;Cheng, Chih-Ming;Juan, Chi-Hung;Chen, Mu-Hong;Chang, Chi-Fu;Lu, Hsin Jie;Su, Tung-Ping;Lee, Ying-Chiao;Li, Cheng-Ta |
| 貢獻者: | 生醫理工學院認知神經科學研究所 |
| 關鍵詞: | Adult;Aged;Brain stimulation;Cognition;Cognition - physiology;Cognitive function;Depressive Disorder, Treatment-Resistant;Depressive Disorder, Treatment-Resistant - physiopathology;Depressive Disorder, Treatment-Resistant - therapy;Executive Function;Executive Function - physiology;Female;Humans;Male;Medication-resistant depression;Middle Aged;Neuropsychological Tests;Prefrontal Cortex;Prefrontal Cortex - physiopathology;Theta-burst stimulation;Transcranial Magnetic Stimulation;Transcranial Magnetic Stimulation - methods;Treatment Outcome;Young Adult |
| 日期: | 2016-04-03 |
| 上傳時間: | 2026-04-23 14:22:48 (UTC+8) |
| 出版者: | England: Elsevier Inc |
| 摘要: | 摘要： Even during symptomatic remission, many patients with medication resistant depression (MRD) still demonstrate impaired cognitive function, especially executive function (EF). Theta-burst transcranial magnetic stimulation (TBS) modulates cortical excitability and may treat MRD. Evidences from previous studies show that intermittent TBS (iTBS) produces cortical excitatory effects, while continuous TBS (cTBS) produces a reduction of cortical excitability. EF is highly dependent on prefrontal activity, but the effects of different forms of prefrontal TBS on EF remain unknown. 60 MRD patients were recruited and randomly assigned to one of four groups. Treatment was determined by the group to which an individual was assigned; A: cTBS 1800pulses/session; B: iTBS 1800pulses/session; C: a combination of cTBS+iTBS, 1800pulses/session for each; and D: sham TBS. Wisconsin Card Sorting Test (WCST) for the performance of EF was evaluated before and after 10 daily treatment sessions Repeated measures ANOVA, with each WCST index at baseline and 2weeks after TBS as within-subject factors, demonstrated that a statistically significant interaction of TBS groups (G) and antidepressant responses [(R), responses were defined as >50% reduction of depression scores after 2-weeks TBS treatment] on the before-versus-after changes of all WCST indexes (G×R, p<0.05). Responders in Group B, but not in the other groups, showed a significant improvement in WCST performance. Only nonresponders in Group A showed a trend for EF worsening. Our findings showed that left prefrontal iTBS, not right prefrontal cTBS, improved EF, and this can be independent from its antidepressant effects. •We performed first double-blind sham-controlled study with four different stimulation of theta-burst stimulation.•Our study was a direct comparison of left and right prefrontal TBS and a combination of them•The better parameter for prefrontal TBS in the treatment of depression was left prefrontal iTBS alone.•Cognitive-enhancing effect of the left prefrontal iTBS seems to be independent from antidepressant effects.
其他題名： Prog Neuropsychopharmacol Biol Psychiatry
出版者： England: Elsevier Inc
出版日期： 2016-04-03
出處： Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2016-04, Vol.66, p.35-40
版權： 2015 Elsevier Inc.
版權： Copyright © 2015 Elsevier Inc. All rights reserved.
識別號： ISSN: 0278-5846
識別號： EISSN: 1878-4216
識別號： DOI: 10.1016/j.pnpbp.2015.11.009
識別號： PMID: 26593273 |
| 顯示於類別: | [認知與神經科學研究所 ] 期刊論文
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