FMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG

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題名:	FMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG
作者:	郭文瑞;Lin, Fa-Hsuan;Witzel, Thomas;Raij, Tommi;Ahveninen, Jyrki;Wen-Kai Tsai, Kevin;Chu, Yin-Hua;Chang, Wei-Tang;Nummenmaa, Aapo;Polimeni, Jonathan R.;Kuo, Wen-Jui;Hsieh, Jen-Chuen;Rosen, Bruce R.;Belliveau, John W.
貢獻者:	生醫理工學院認知神經科學研究所
關鍵詞:	Adult;Biological and medical sciences;BOLD;Brain - physiology;Brain Mapping;Brain research;Electroencephalography;Experiments;Female;Fundamental and applied biological sciences. Psychology;Hemodynamics;Hemodynamics - physiology;Humans;Image Processing, Computer-Assisted;Inverse imaging;Latency;Magnetic Resonance Imaging;Magnetoencephalography;Male;Medical research;Neuronal timing;Neurons - physiology;Neurovascular coupling;Photic Stimulation;Reaction Time - physiology;Studies;Vertebrates: nervous system and sense organs;Young Adult
日期:	2013-09-01
上傳時間:	2026-04-23 14:26:42 (UTC+8)
出版者:	Academic Press Inc.;Amsterdam: Elsevier Inc
摘要:	摘要： Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100ms; all delays ≥400ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain. •fMRI at 100ms resolution and MEG were recorded in a visuomotor reaction-time task.•Interregional BOLD and MEG response delays are linearly correlated.•The smallest significant interregional BOLD delay was 100ms.•All BOLD delays ≥400ms were significant.•Switching the order of external events reversed the sequence of BOLD activations. 其他題名： Neuroimage 出版者： Amsterdam: Elsevier Inc 出版日期： 2013-09-01 出處： NeuroImage, 2013-09, Vol.78, p.372-384 版權： 2013 Elsevier Inc. 版權： 2014 INIST-CNRS 版權： Copyright © 2013 Elsevier Inc. All rights reserved. 版權： Copyright Elsevier Limited Sep 1, 2013 識別號： ISSN: 1053-8119 識別號： ISSN: 1095-9572 識別號： EISSN: 1095-9572 識別號： DOI: 10.1016/j.neuroimage.2013.04.017 識別號： PMID: 23591071
顯示於類別:	[認知與神經科學研究所 ] 期刊論文

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