Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity

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題名:	Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity
作者:	黃英儒;Hsieh, Tsung-Hsun;Huang, Ying-Zu;Rotenberg, Alexander;Pascual-Leone, Alvaro;Chiang, Yung-Hsiao;Wang, Jia-Yi;Chen, Jia-Jin J
貢獻者:	生醫理工學院認知神經科學研究所
關鍵詞:	Animals;Dopaminergic Neurons - pathology;Dopaminergic Neurons - physiology;Electromyography;Evoked Potentials, Motor - physiology;Male;Motor Cortex - pathology;Motor Cortex - physiology;Motor Cortex - physiopathology;Muscle, Skeletal - physiology;Muscle, Skeletal - physiopathology;Neuronal Plasticity - physiology;Oxidopamine;Parkinsonian Disorders - pathology;Parkinsonian Disorders - physiopathology;Rats, Wistar;Severity of Illness Index;Substantia Nigra - pathology;Substantia Nigra - physiology;Substantia Nigra - physiopathology;Transcranial Magnetic Stimulation - methods
日期:	2015-07-01
上傳時間:	2026-04-23 14:27:00 (UTC+8)
出版者:	Oxford University Press;United States: Oxford University Press (OUP)
摘要:	摘要： Repetitive magnetic stimulation (rTMS), including theta burst stimulation (TBS), is capable of modulating motor cortical excitability through plasticity-like mechanisms and might have therapeutic potential for Parkinson's disease (PD). An animal model would be helpful for elucidating the mechanism of rTMS that remain unclear and controversial. Here, we have established a TMS model in rat and applied this model to study the impact of substantia nigra dopamine neuron on TBS-induced motor plasticity in PD rats. In parallel with human results, continuous TBS (cTBS) successfully suppressed motor evoked potentials (MEPs), while MEPs increased after intermittent TBS (iTBS) in healthy rats. We then tested the effect of iTBS in early and advanced 6-hydroxydopamine (6-OHDA)-lesioned PD. Moreover, dopaminergic neurons in substantia nigra and rotation behavior were assessed to correlate with the amount of iTBS-induced plasticity. In results, iTBS-induced potentiation was reduced in early PD rats and was absent in advanced PD rats. Such reduction in plasticity strongly correlated with the dopaminergic cell loss and the count of rotation in PD rats. In conclusion, we have established a TMS PD rat model. With the help of this model, we confirmed the loss of domaninergic neurons in substantia nigra resulting in reduced rTMS-induced motor plasticity in PD. 其他題名： Cereb Cortex 出版者： United States: Oxford University Press (OUP) 出版日期： 2015-07-01 出處： Cerebral Cortex, 2015-07, Vol.25 (7), p.1806-1814 版權： The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissionsoup.com. 識別號： ISSN: 1047-3211 識別號： ISSN: 1460-2199 識別號： EISSN: 1460-2199 識別號： DOI: 10.1093/cercor/bht421 識別號： PMID: 24451657
顯示於類別:	[認知與神經科學研究所 ] 期刊論文

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