Neuromagnetic index of hemispheric asymmetry prognosticating the outcome of sudden hearing loss

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Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/107878

Title:	Neuromagnetic index of hemispheric asymmetry prognosticating the outcome of sudden hearing loss
Authors:	李柏磊;Li, Lieber Po-Hung;Shiao, An-Suey;Chen, Kuang-Chao;Lee, Po-Lei;Niddam, David M.;Chang, Shyue-Yih;Hsieh, Jen-Chuen
Contributors:	資訊電機學院電機工程學系
Keywords:	Acoustic Stimulation;Adult;Aged;Asymmetry;Auditory plasticity;Biology;Brain;Brain - physiopathology;Brain research;Congenital diseases;Deafness;Dominance;Ear;Education;Epidemiology;Evoked Potentials, Auditory - physiology;Female;Functional Laterality - physiology;Hearing loss;Hearing Loss, Sudden - physiopathology;Hemispheric laterality;Hospitals;Humans;Laboratories;Latency;Lesions;Magnetic fields;Magnetoencephalography;Male;Medical prognosis;Medical research;Medicine;Middle Aged;Neurophysiology;NMR;Nuclear magnetic resonance;Otolaryngology;Plastic properties;Plasticity;Prognosis;Recovery;Rheology;Sensory stimulation;Subgroups
Date:	2012-04-20
Issue Date:	2026-04-23 14:27:48 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science (PLoS)
Abstract:	摘要： The longitudinal relationship between central plastic changes and clinical presentations of peripheral hearing impairment remains unknown. Previously, we reported a unique plastic pattern of "healthy-side dominance" in acute unilateral idiopathic sudden sensorineural hearing loss (ISSNHL). This study aimed to explore whether such hemispheric asymmetry bears any prognostic relevance to ISSNHL along the disease course. Using magnetoencephalography (MEG), inter-hemispheric differences in peak dipole amplitude and latency of N100m to monaural tones were evaluated in 21 controls and 21 ISSNHL patients at two stages: initial and fixed stage (1 month later). Dynamics/Prognostication of hemispheric asymmetry were assessed by the interplay between hearing level/hearing gain and ipsilateral/contralateral ratio (I/C) of N100m latency and amplitude. Healthy-side dominance of N100m amplitude was observed in ISSNHL initially. The pattern changed with disease process. There is a strong correlation between the hearing level at the fixed stage and initial I/C(amplitude) on affected-ear stimulation in ISSNHL. The optimal cut-off value with the best prognostication effect for the hearing improvement at the fixed stage was an initial I/C(latency) on affected-ear stimulation of 1.34 (between subgroups of complete and partial recovery) and an initial I/C(latency) on healthy-ear stimulation of 0.76 (between subgroups of partial and no recovery), respectively. This study suggested that a dynamic process of central auditory plasticity can be induced by peripheral lesions. The hemispheric asymmetry at the initial stage bears an excellent prognostic potential for the treatment outcomes and hearing level at the fixed stage in ISSNHL. Our study demonstrated that such brain signature of central auditory plasticity in terms of both N100m latency and amplitude at defined time can serve as a prognostication predictor for ISSNHL. Further studies are needed to explore the long-term temporal scenario of auditory hemispheric asymmetry and to get better psychoacoustic correlates of pathological hemispheric asymmetry in ISSNHL. 其他題名： PLoS One 出版者： United States: Public Library of Science (PLoS) 出版日期： 2012-04-20 出處： PLoS ONE, 2012-04, Vol.7 (4), p.e35055- 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2012 Public Library of Science 版權： 2012 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： Li et al. 2012 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0035055 識別號： PMID: 22532839
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