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| 題名: | Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease |
| 作者: | 黃英儒;Chiu, Ching-Chi;Yeh, Tu-Hsueh;Lai, Szu-Chia;Weng, Yi-Hsin;Huang, Yin-Cheng;Cheng, Yi-Chuan;Chen, Rou-Shayn;Huang, Ying-Zu;Hung, June;Chen, Chiung-Chu;Lin, Wey-Yil;Chang, Hsiu-Chen;Chen, Yu-Jie;Chen, Chao-Lang;Chen, Hsin-Yi;Lin, Yan-Wei;Wu-Chou, Yah-Huei;Wang, Hung-Li;Lu, Chin-Song |
| 貢獻者: | 生醫理工學院認知神經科學研究所 |
| 關鍵詞: | alpha-Synuclein - secretion;Animals;Biomarkers - analysis;Cells, Cultured;Humans;Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - physiology;Mice;Mice, Transgenic;Parkinson Disease - diagnosis;Parkinson Disease - etiology;rab GTP-Binding Proteins - analysis;Research Paper: Gerotarget (Focus on Aging);Substantia Nigra - chemistry |
| 日期: | 2016-01-01 |
| 上傳時間: | 2026-04-23 14:27:51 (UTC+8) |
| 出版者: | Impact Journals LLC;United States: Impact Journals, LLC |
| 摘要: | 摘要： Parkinson's disease (PD) is the second common neurodegenerative disease. Identification of biomarkers for early diagnosis and prediction of disease progression is important. The present comparative proteomic study of serum samples using two-dimensional fluorescence differential gel electrophoresis followed by ELISA confirmation demonstrated that protein expression of Rab35 was increased in PD patients compared with matched control subjects and other parkinsonian disorders, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). The serum level of Rab35 was significantly correlated with the age at onset of PD. The median age of onset in patients with higher Rab35 serum level was 5 years younger than those with lower Rab35 serum level. There was a positive correlation between the Rab35 level and disease duration of PD. Moreover, the protein expression of Rab35 was increased in the substantia nigra but not in the striatum of mouse models of PD, including MPTP-treated mice, rotenone-treated mice, (R1441C) LRRK2 or (G2019S) LRRK2 transgenic mice. Furthermore, overexpression of Rab35 increased the aggregation and secretion of mutant A53T α-synuclein in dopaminergic SH-SY5Y cells. Co-expression of Rab35 with wild-type or A53T α-synuclein in SH-SY5Y cells deteriorated cell death. Our results suggest that Rab35 is potentially useful in the differential diagnosis of parkinsonian disorders and is implicated in the pathogenesis of PD.
其他題名： Oncotarget
出版者： United States: Impact Journals, LLC
出版日期： 2016-08-23
出處： Oncotarget, 2016-08, Vol.7 (34), p.54215-54227
版權： Copyright: © 2016 Chiu et al. 2016
識別號： ISSN: 1949-2553
識別號： EISSN: 1949-2553
識別號： DOI: 10.18632/oncotarget.11090
識別號： PMID: 27509057 |
| 顯示於類別: | [認知與神經科學研究所 ] 期刊論文
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