Investigation of motor cortical plasticity and corticospinal tract diffusion tensor imaging in patients with parkinsons disease and essential tremor

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题名:	Investigation of motor cortical plasticity and corticospinal tract diffusion tensor imaging in patients with parkinsons disease and essential tremor
作者:	段正仁;Lu, Ming-Kuei;Chen, Chun-Ming;Duann, Jeng-Ren;Ziemann, Ulf;Chen, Jui-Cheng;Chiou, Shang-Ming;Tsai, Chon-Haw
贡献者:	生醫理工學院認知神經科學研究所
关键词:	Age;Aged;Analysis of Variance;Anisotropy;Biology and Life Sciences;Care and treatment;Comparative analysis;Cortex (motor);Demography;Diagnostic imaging;Diffusion;Diffusion Tensor Imaging - methods;Essential Tremor - complications;Essential Tremor - physiopathology;Evoked Potentials, Motor - physiology;Evoked Potentials, Somatosensory - physiology;Excitability;Female;Hospitals;Humans;Laboratories;Long-term potentiation;Magnetic resonance imaging;Male;Median Nerve - physiopathology;Medical imaging;Medicine;Medicine and Health Sciences;Motivation;Motor Cortex - physiopathology;Motor evoked potentials;Movement disorders;Neural plasticity;Neurodegenerative diseases;Neuroimaging;Neurological disorders;Neurology;Neuronal Plasticity - physiology;Neuroplasticity;Neurosciences;Paired-Associate Learning;Parkinson Disease - physiopathology;Parkinson's disease;Physical Sciences;Plastic properties;Plasticity;Pyramidal tracts;Pyramidal Tracts - physiopathology;Research and Analysis Methods;Sensory Thresholds - physiology;Studies;Transcranial Magnetic Stimulation;Tremor
日期:	2016-09-01
上传时间:	2026-04-23 14:29:01 (UTC+8)
出版者:	Public Library of Science;United States: Public Library of Science
摘要:	摘要： Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention tremor and healthy controls (HC) were studied. The primary motor cortex (M1) excitability, measured by motor evoked potential (MEP) amplitude and by short-interval and long-interval intracortical inhibition (SICI and LICI) was compared between the three groups before and after PAS. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were acquired. PAS effects and DTI data were simultaneously examined between groups. PAS increased MEP amplitude in HC but not in PD and ET. SICI and LICI were significantly reduced after PAS irrespective of groups. No significant differences of the mean FA and MD were found between groups. There was no significant correlation between the PAS effects and the DTI measures. Findings suggest that both PD and ET with intention tremor have impairment of the associative LTP-like corticospinal excitability change in M1. The microstructure of the CST is not relevant to the deficiency of M1 associative plasticity in PD and ET. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2016-09-07 出處： PloS one, 2016-09, Vol.11 (9), p.e0162265 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2016 Public Library of Science 版權： 2016 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2016 Lu et al 2016 Lu et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0162265 識別號： PMID: 27603204
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