Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex

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題名:	Modulating the interference effect on spatial working memory by applying transcranial direct current stimulation over the right dorsolateral prefrontal cortex
作者:	阮啓弘;Wu, Yi-Jen;Tseng, Philip;Chang, Chi-Fu;Pai, Ming-Chyi;Hsu, Kuei-Sen;Lin, Chou-Ching;Juan, Chi-Hung
貢獻者:	生醫理工學院認知神經科學研究所
關鍵詞:	Adult;Attention - physiology;Biological and medical sciences;Corsi Block Tapping task;Dorsolateral prefrontal cortex;Female;Fundamental and applied biological sciences. Psychology;Human;Humans;Interference effect;Learning. Memory;Male;Memory;Memory, Short-Term - physiology;Mental Recall - physiology;Neuropsychological Tests;Prefrontal Cortex - physiology;Psychology. Psychoanalysis. Psychiatry;Psychology. Psychophysiology;Reaction Time;Spatial working memory;Top-down control;Transcranial direct current stimulation;Transcranial Direct Current Stimulation - methods;Transcranial Magnetic Stimulation - methods;Visual short-term memory;Visual working memory;Visuospatial working memory;Young Adult
日期:	2014-11-01
上傳時間:	2026-04-23 14:29:32 (UTC+8)
出版者:	Academic Press Inc.;Amsterdam: Elsevier Inc
摘要:	摘要： Spatial working memory (SWM) is the ability to temporarily store and manipulate spatial information. It has a limited capacity and is quite vulnerable to interference. Dorsolateral prefrontal cortex (DLPFC) has been shown to be a part of the SWM network but its specific functional role still remains unknown. Here we applied transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique that provides polarity-specific stimulation over the targeted region, to investigate the specific role of the right DLPFC in resolving interference in SWM. A forward- and backward-recall computerized Corsi Block Tapping task (CBT), both with and without a concurrent motor interference task (the modified Luria manual sequencing task) was used to measure SWM capacity and reaction time. The results showed that motor interference impeded accuracy and prolonged reaction time in forward and backward recall for SWM. Anodal tDCS over right DLPFC yielded the tendency to shorten participants’ reaction time in the conditions with interference (forward with interference, and backward with interference). Most importantly, anodal tDCS significantly improved participants’ SWM span when cognitive demand was the highest (the “backward-recall with motor interference” condition). These results suggest that (1) the right DLPFC plays a crucial role in dealing with the cross-domain motor interference for spatial working memory and (2) the anodal tDCS over right DLPFC improved SWM capacity particularly when task difficulty demands more complex mental manipulations that could be due to the facilitatory effect of anodal tDCS which enhanced the DLPFC function within central executive system at the top-down attentional level. 其他題名： Brain Cogn 出版者： Amsterdam: Elsevier Inc 出版日期： 2014-11-01 出處： Brain and Cognition, 2014-11, Vol.91, p.87-94 版權： 2014 Elsevier Inc. 版權： 2015 INIST-CNRS 版權： Copyright © 2014 Elsevier Inc. All rights reserved. 識別號： ISSN: 0278-2626 識別號： ISSN: 1090-2147 識別號： EISSN: 1090-2147 識別號： DOI: 10.1016/j.bandc.2014.09.002 識別號： PMID: 25265321 識別號： CODEN: BRCOEI
顯示於類別:	[認知與神經科學研究所 ] 期刊論文

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