Potential therapeutic role of hispidulin in gastric cancer through induction of apoptosis via NAG-1 signaling

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Title:	Potential therapeutic role of hispidulin in gastric cancer through induction of apoptosis via NAG-1 signaling
Authors:	李柏磊;Yu, Chao Yuan;Su, Kang-Yi;Lee, Po-Lei;Jhan, Jie-Yu;Tsao, Po-Hung;Chan, De-Chuan;Chen, Yi-Lin Sophia
Contributors:	資訊電機學院電機工程學系
Keywords:	Acetic acid;Apoptosis;Blood-brain barrier;Breast cancer;Cancer therapies;Cell cycle;Cell proliferation;Colorectal cancer;Cyclin D1;Cyclin E;Cyclin-dependent kinase inhibitor p21;Cyclooxygenase-2;EGR-1 protein;Ethyl acetate;Flow cytometry;Gastric cancer;Kinases;Ligands;Nonsteroidal anti-inflammatory drugs;p53 Protein;Prognosis;Protein expression;Proteins;S phase;Tumor cells
Date:	2013-10-21
Issue Date:	2026-04-23 14:31:43 (UTC+8)
Publisher:	Cairo, Egypt: Hindawi Puplishing Corporation
Abstract:	摘要： Gastric cancer is one of the most common malignant cancers due to poor prognoses and high mortality rates worldwide. However, an effective chemotherapeutic drug without side effects remains lacking. Saussurea involucrata (SI) Kar. et Kir., also known as snow lotus, grows in mountainous rocky habitats at 2600 m elevation in the Tian Shan and A’er Tai regions of China. The ethyl acetate extract of SI had been shown to inhibit proliferation and induce apoptosis in various tumor cells. In this study, we demonstrated that Hispidulin, active ingredients in SI, inhibits the growth of AGS gastric cancer cells. After Hispidulin treatment, NAG-1 remained highly expressed, whereas COX-2 expression was downregulated. Flow cytometric analysis indicated that Hispidulin induces G1/S phase arrest and apoptosis in time- and concentration-dependent manners. G1/S arrest correlated with upregulated p21/WAF1 and p16 and downregulated cyclin D1 and cyclin E, independent of p53 pathway. In addition, Hispidulin can elevate Egr-1 expression and ERK1/2 activity, whereas ERK1/2 inhibitor markedly attenuated NAG-1 mediated apoptosis. Taken together, Hispidulin can efficiently activate ERK1/2 signaling followed by NAG-1 constitutive expression and trigger cell cycle arrest as well as apoptosis in cancer cell. It can be a potential compound for combination therapy of gastric cancer in the future. 其他題名： Evid Based Complement Alternat Med 出版者： Cairo, Egypt: Hindawi Puplishing Corporation 出版日期： 2013-01-01 出處： Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-12 資源來源： Publicly Available Content Database 版權： Copyright © 2013 Chao Yuan Yu et al. 版權： Copyright © 2013 Chao Yuan Yu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 版權： Copyright © 2013 Chao Yuan Yu et al. 2013 識別號： ISSN: 1741-427X 識別號： ISSN: 1741-4288 識別號： EISSN: 1741-4288 識別號： DOI: 10.1155/2013/518301 識別號： PMID: 24159347
Appears in Collections:	[Department of Electrical Engineering] journal & Dissertation

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