Predictability effect on N400 reflects the severity of reading comprehension deficits in aphasia

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Title:	Predictability effect on N400 reflects the severity of reading comprehension deficits in aphasia
Authors:	李佳穎;Chang, Chih-Ting;Lee, Chia-Ying;Chou, Chia-Ju;Fuh, Jong-Ling;Wu, Hsin-Chi
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Adult;Aged;Anterior shift of N400;Aphasia;Aphasia - complications;Brain Mapping;Case-Control Studies;Comprehension - physiology;Dyslexia - etiology;Electroencephalography;ERPs;Evoked Potentials - physiology;Female;Humans;Male;Middle Aged;Neuropsychological Tests;Predictability;Predictive Value of Tests;Reading comprehension;Severity of Illness Index;Young Adult
Date:	2016-01-29
Issue Date:	2026-04-23 14:33:16 (UTC+8)
Publisher:	Elsevier Ltd.;England: Elsevier Ltd
Abstract:	摘要： Predictability effect on N400, in which low predictability words elicited a larger N400 than high predictability words did over central to posterior electrodes, has been used to index difficulty of lexical retrieval and semantic integration of words in sentence comprehension. This study examined predictability effect on N400 in aphasic patients to determine if the properties of N400 are suited to indexing the severity of reading comprehension deficits. Patients with aphasia were divided into high and low ability groups based on scores on the reading comprehension subtest in the Chinese Concise Aphasia Test (CCAT). The two aphasia groups, a group of healthy elders who were age-matched to the aphasic participants, and a group of young adults, were requested to read sentences that either ended with highly predictable words or unexpected but plausible words, while undergoing electroencephalography (EEG). The young adult and healthy elderly groups exhibited the typical centro-parietal distributed effect of predictability on N400; however, healthy elders exhibited a reduced N400 effect in a delayed time window compared to the young adults. Compared with the elderly control, the high ability aphasia group exhibited a comparable N400 effect in a more restricted time window; by contrast, the low ability aphasia group exhibited a frontal distributed N400 in a much later time window (400–700ms). These data suggest that the severity of reading comprehension deficits affects predictability effect on a set of N400 characteristics (i.e., amplitude, time window, and topographic distribution), which may be effective as ERP signatures in the evaluation of language recovery in aphasia. •Reading comprehension deficits in aphasia modulated predictability effect on N400.•Patients with higher comprehension ability are more likely to show the typical N400.•Low reading ability aphasics showed a prolonged and anterior-shifting N400 effect.•The anterior-shift N400 may due to lesion or a greater reliance on frontal mechanism.•Characteristics of N400 may index comprehension deficits and recovery in aphasia. 其他題名： Neuropsychologia 出版者： England: Elsevier Ltd 出版日期： 2016-01-29 出處： Neuropsychologia, 2016-01, Vol.81, p.117-128 版權： 2015 Elsevier Ltd 版權： Copyright © 2015 Elsevier Ltd. All rights reserved. 識別號： ISSN: 0028-3932 識別號： ISSN: 1873-3514 識別號： EISSN: 1873-3514 識別號： DOI: 10.1016/j.neuropsychologia.2015.12.002 識別號： PMID: 26686551
Appears in Collections:	[College of Science Institute of Cognitive Neuroscience] journal & Dissertation

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