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| 題名: | Pupil size reveals preparatory processes in the generation of pro-saccades and anti-saccades |
| 作者: | 汪勁安;Wang, Chin-An;Brien, Donald C.;Munoz, Douglas P. |
| 貢獻者: | 生醫理工學院認知神經科學研究所 |
| 關鍵詞: | Adult;executive function;Fixation, Ocular;frontal eye field;Humans;Photic Stimulation;preparatory set;Psychomotor Performance;Pupil - physiology;pupil dilation;Reaction Time;Saccades;superior colliculus;Young Adult |
| 日期: | 2015-04-01 |
| 上傳時間: | 2026-04-23 14:34:12 (UTC+8) |
| 出版者: | Wiley-Blackwell Publishing Ltd;France: Blackwell Publishing Ltd |
| 摘要: | 摘要： AbstractThe ability to generate flexible behaviors to accommodate changing goals in response to identical sensory stimuli is a signature that is inherited in humans and higher‐level animals. In the oculomotor system, this function has often been examined with the anti‐saccade task, in which subjects are instructed, prior to stimulus appearance, to either automatically look at the peripheral stimulus (pro‐saccade) or to suppress the automatic response and voluntarily look in the opposite direction from the stimulus (anti‐saccade). Distinct neural preparatory activity between the pro‐saccade and anti‐saccade conditions has been well documented, particularly in the superior colliculus (<jats:styled-content style="fixed-case">SC</jats:styled-content>) and the frontal eye field (<jats:styled-content style="fixed-case">FEF</jats:styled-content>), and this has shown higher inhibition‐related fixation activity in preparation for anti‐saccades than in preparation for pro‐saccades. Moreover, the level of preparatory activity related to motor preparation is negatively correlated with reaction times. We hypothesised that preparatory signals may be reflected in pupil size through a link between the <jats:styled-content style="fixed-case">SC</jats:styled-content> and the pupil control circuitry. Here, we examined human pupil dynamics during saccade preparation prior to the execution of pro‐saccades and anti‐saccades. Pupil size was larger in preparation for correct anti‐saccades than in preparation for correct pro‐saccades and erroneous pro‐saccades made in the anti‐saccade condition. Furthermore, larger pupil dilation prior to stimulus appearance accompanied saccades with faster reaction times, with a trial‐by‐trial correlation between dilation size and anti‐saccade reaction times. Overall, our results demonstrate that pupil size is modulated by saccade preparation, and neural activity in the <jats:styled-content style="fixed-case">SC</jats:styled-content>, together with the <jats:styled-content style="fixed-case">FEF</jats:styled-content>, supports these findings, providing unique insights into the neural substrate coordinating cognitive processing and pupil diameter.
其他題名： Eur J Neurosci
出版者： France: Blackwell Publishing Ltd
出版日期： 2015-04
出處： European Journal of Neuroscience, 2015-04, Vol.41 (8), p.1102-1110
資源來源： Wiley Online Library All Journals
版權： 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
版權： 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
識別號： ISSN: 0953-816X
識別號： ISSN: 1460-9568
識別號： EISSN: 1460-9568
識別號： DOI: 10.1111/ejn.12883
識別號： PMID: 25817064 |
| 顯示於類別: | [認知與神經科學研究所 ] 期刊論文
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