Quantifying cerebellar atrophy in multiple system atrophy of the cerebellar type (MSA-C) using three-dimensional gyrification index analysis

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題名:	Quantifying cerebellar atrophy in multiple system atrophy of the cerebellar type (MSA-C) using three-dimensional gyrification index analysis
作者:	徐國鎧;Wu, Yu-Te;Shyu, Kuo-Kai;Jao, Chii-Wen;Liao, Yuan-Lin;Wang, Tzu-Yun;Wu, Hsiu-Mei;Wang, Po-Shan;Soong, Bing-Wen
貢獻者:	資訊電機學院電機工程學系
關鍵詞:	Adult;Age;Aged;Aging - physiology;Algorithms;Analysis of Variance;Ataxia;Atrophy;Brain;Cerebellum;Cerebellum - pathology;Data Interpretation, Statistical;Disease;Female;Gender differences;Gyrification index;Humans;Image Processing, Computer-Assisted;Imaging, Three-Dimensional;Magnetic Resonance Imaging;Male;Methods;Middle Aged;MSA-C;Multiple System Atrophy - pathology;Neuroimaging;Patients;Reference Values;Sex Characteristics;Standard deviation;Studies;Volumetric analysis
日期:	2012-05-15
上傳時間:	2026-04-23 14:34:16 (UTC+8)
出版者:	United States: Elsevier Inc
摘要:	摘要： Multiple system atrophy of the cerebellar type (MSA-C) is a degenerative neurological disease of the central nervous system. This study employed a method named, “surface-based three-dimensional gyrification index” (3D-GI) to quantify morphological changes in normal cerebellum (including brainstem) and atrophied cerebellum, in patients with MSA-C. We assessed whether 3D-GI can exclude gender and age differences to quantify cerebellum and brainstem atrophy more accurately. Sixteen healthy subjects and 16 MSA-C patients participated in this study. We compared 3D-GI values and volumes in the cerebellum, based on T1-weighted MR images. We also compared the images of reconstructed 3D cerebellum gray matter (3D-CBGM) and cerebellum white matter (3D-CBWM) to detect the atrophied cerebellar region in MSA-C patients. The 3D-GI values were in a stable range with small variances, exhibiting no gender effect and no age-related shrinkage. Significantly lower 3D-GI values were exhibited in both CBGM and CBWM of the MSA-C patients compared with healthy subjects, even in the early phases of the disease. Decreases in 3D-GI values indicated the degeneration of the cerebellar folding structure, exactly reflecting the morphological changes in cerebellum. The 3D-GI method based on CBGM resulted in superior discriminative accuracy compared with the CBGM volumetric method. Using the two-dimensional 3D-GI values, the K-means classifier can evidently discriminate the MSA-C patients from healthy subjects. 其他題名： Neuroimage 出版者： United States: Elsevier Inc 出版日期： 2012-05-15 出處： NeuroImage (Orlando, Fla.), 2012-05, Vol.61 (1), p.1-9 版權： 2012 Elsevier Inc. 版權： Copyright © 2012 Elsevier Inc. All rights reserved. 版權： Copyright Elsevier Limited May 15, 2012 識別號： ISSN: 1053-8119 識別號： ISSN: 1095-9572 識別號： EISSN: 1095-9572 識別號： DOI: 10.1016/j.neuroimage.2012.02.057 識別號： PMID: 22401757
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