Roles of the pre-SMA and rIFG in conditional stopping revealed by transcranial magnetic stimulation

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Title:	Roles of the pre-SMA and rIFG in conditional stopping revealed by transcranial magnetic stimulation
Authors:	阮啓弘;Lee, Hon Wah;Lu, Ming-Shan;Chen, Chiao-Yun;Muggleton, Neil G.;Hsu, Tzu-Yu;Juan, Chi-Hung
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Adult;Brain Mapping;Conditional stop-signal task;Executive Function - physiology;Female;Frontal Lobe - physiology;Humans;Inhibition (Psychology);Inhibitory control;Male;Pre-supplementary motor area;Psychomotor Performance - physiology;Right inferior prefrontal gyrus;Theta Rhythm - physiology;Transcranial magnetic stimulation;Transcranial Magnetic Stimulation - methods;Young Adult
Date:	2016-01-01
Issue Date:	2026-04-23 14:37:08 (UTC+8)
Publisher:	Elsevier;Netherlands: Elsevier B.V
Abstract:	摘要： •Disruption of pre-SMA activity impaired the continue process in low-slowing participants.•Disruption of rIFG activity did not significantly affect response slowing.•Pre-SMA’s efficiency in reinitiating an inhibited response may be related to response slowing. Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA and the rIFG in a conditional stop-signal task by applying offline theta-burst transcranial magnetic stimulation. The task introduced a continue condition, which requires the same motor response as in a go trial but captures attention as in a stop trial. We found great individual differences in the amount of slowing on continue trials. Temporary suppression of pre-SMA activity prolonged the continue RT in participants who slowed little in response to continue trials, whereas disruption of the rIFG did not lead to significant changes in performance irrespective of the degree of slowing. Our results contribute to the understanding of the role of the pre-SMA by providing causal evidence that it is involved in response slowing on continue trials during conditional stopping, and it is likely that its efficiency in updating motor planning and reinitiating an inhibited response was associated with the amount of slowing. 其他題名： Behav Brain Res 出版者： Netherlands: Elsevier B.V 出版日期： 2016-01-01 出處： Behavioural Brain Research, 2016-01, Vol.296, p.459-467 版權： 2015 Elsevier B.V. 版權： Copyright © 2015 Elsevier B.V. All rights reserved. 識別號： ISSN: 0166-4328 識別號： EISSN: 1872-7549 識別號： DOI: 10.1016/j.bbr.2015.08.024 識別號： PMID: 26304720
Appears in Collections:	[College of Science Institute of Cognitive Neuroscience] journal & Dissertation

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