Suppression of cardiac alternans by alternating-period-feedback stimulations

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/108158

Title:	Suppression of cardiac alternans by alternating-period-feedback stimulations
Authors:	黎璧賢;Sridhar, S.;Le, Duy-Manh;Mi, Yun-Chieh;Sinha, Sitabhra;Lai, Pik-Yin;Chan, C. K.
Contributors:	理學院物理學系
Keywords:	Algorithms;Animals;Biological Clocks - physiology;Feedback, Physiological - physiology;Female;Heart - physiology;Male;Models, Biological;Rats;Rats, Wistar
Date:	2013-04-15
Issue Date:	2026-04-23 14:37:28 (UTC+8)
Publisher:	American Physical Society;United States
Abstract:	摘要： Alternans response, comprising a sequence of alternating long and short action potential durations in heart tissue, seen during rapid periodic pacing can lead to conduction block resulting in potentially fatal cardiac failure. A method of pacing with feedback control is proposed to reduce the alternans and therefore the probability of subsequent cardiac failure. The reduction is achieved by feedback control using small perturbations of constant magnitude to the original, alternans-generating pacing period T, viz., using sequences of two alternating periods of T+ΔT and T-ΔT, with ΔT<<T. Such a control scheme for alternans suppression is demonstrated experimentally in isolated whole heart experiments. This alternans suppression scheme is further confirmed and investigated in detail by simulations of ion-channel-based cardiac models both for a single cell and in one-dimensional spatially extended systems. The mechanism of the success of our method can be understood in terms of dynamics in phase space, viz., as the state of activity of the cell being confined within a narrow volume of phase space for the duration of control, resulting in extremely diminished variation in successive action potential durations. Our method is much more robust to noise than previous alternans reduction techniques based on fixed point stabilization and should thus be more efficient in terms of experimental implementation, which has implications for clinical treatment for arrhythmia. 其他題名： Phys Rev E Stat Nonlin Soft Matter Phys 出版者： United States 出版日期： 2013-04 出處： Physical review. E, Statistical, nonlinear, and soft matter physics, 2013-04, Vol.87 (4), p.042712, Article 042712 識別號： ISSN: 1539-3755 識別號： ISSN: 1550-2376 識別號： EISSN: 1550-2376 識別號： DOI: 10.1103/PhysRevE.87.042712 識別號： PMID: 23679454
Appears in Collections:	[Department of Physics] journal & Dissertation

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