A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis

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Title:	A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis
Authors:	周鼎贏;Chou, Dean;Vardakis, John C.;Guo, Liwei;Tully, Brett J.;Ventikos, Yiannis
Contributors:	工學院機械工程學系
Keywords:	Adult;Amalgamation;Aqueduct;Boundary conditions;Cerebrospinal fluid;Cerebrospinal Fluid Pressure;Collaboration;Conflicts of interest;Constants;Delay;Displacement;Dynamical systems;Dynamics;Elasticity;Humans;Hydrocephalus;Hydrocephalus - physiopathology;Mathematical models;Models, Biological;Multiple-network poroelastic theory;Physical Medicine and Rehabilitation;Skull;Stenosis
Date:	2016-07-26
Issue Date:	2026-04-23 14:37:33 (UTC+8)
Publisher:	Elsevier Ltd.;United States: Elsevier Ltd
Abstract:	摘要： This study proposes the implementation of a fully dynamic four-network poroelastic model which is underpinned by multiple-network poroelastic theory (MPET), in order to account for the effects of varying stages of aqueductal stenosis and atresia during acute hydrocephalus. The innovation of the fully dynamic MPET implementation is that it avoids the commonplace assumption of quasi-steady behaviour; instead, it incorporates all transient terms in the casting of the equations and in the numerical solution of the resulting discrete system. It was observed that the application of mild stenosis allows for a constant value of amalgamated ventricular displacement in under 2.4h, whereas the application of a severe stenosis delays this settlement to approximately 10h. A completely blocked aqueduct does not show a clear sign of reaching a steady ventricular displacement after 24h. The increasing ventricular pressure (complemented with ventriculomegaly) during severe stenosis is causing the trans-parenchymal tissue region to respond, and this coping mechanism is most attenuated at the regions closest to the skull and the ventricles. After 9h, the parenchymal tissue shows to be coping well with the additional pressure burden, since both ventriculomegaly and ventricular CSF (cerebrospinal fluid) pressure show small increases between 9 and 24h. Localised swelling in the periventricular region could also be observed through CSF fluid content, whilst dilation results showed stretch and compression of cortical tissue adjacent to the ventricles and skull. 其他題名： J Biomech 出版者： United States: Elsevier Ltd 出版日期： 2016-07-26 出處： Journal of biomechanics, 2016-07, Vol.49 (11), p.2306-2312 資源來源： ProQuest 版權： 2015 The Authors 版權： The Authors 版權： Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. 版權： Copyright Elsevier Limited 2016 識別號： ISSN: 0021-9290 識別號： ISSN: 1873-2380 識別號： EISSN: 1873-2380 識別號： DOI: 10.1016/j.jbiomech.2015.11.025 識別號： PMID: 26671218
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