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| 題名: | Supraspinal characterization of the thermal grill illusion with fMRI |
| 作者: | 段正仁;Leung, Albert;Shukla, Shivshil;Li, Eric;Duann, Jeng-Ren;Yaksh, Tony |
| 貢獻者: | 生醫理工學院認知神經科學研究所 |
| 關鍵詞: | Adolescent;Adult;Aged;Aged, 80 and over;Brain;Brain - blood supply;Brain - physiopathology;Brain Mapping;Burning;Cold;Colleges & universities;Data analysis;Female;Functional magnetic resonance imaging;Hot Temperature;Humans;Illusions - psychology;Image Processing, Computer-Assisted;Linear Models;Magnetic resonance imaging;Male;Medicine;Medicine & Public Health;Middle Aged;Molecular Medicine;Neuralgia;Neurobiology;Neurology;Neurosciences;NMR;Nuclear magnetic resonance;Oxygen - blood;Pain - physiopathology;Pain Measurement;Pain Medicine;Pain Threshold - physiology;Psychophysics;Sensation;Temperature;Thalamus;Thermosensing - physiology;Young Adult |
| 日期: | 2014-03-11 |
| 上傳時間: | 2026-04-23 14:38:20 (UTC+8) |
| 出版者: | BioMed Central Ltd.;Los Angeles, CA: SAGE Publications |
| 摘要: | 摘要： Background: Simultaneous presentation of non-noxious warm (40°C) and cold (20°C) stimuli in an interlacing fashion results in a transient hot burning noxious sensation (matched at 46°C) known as the thermal grill (TG) illusion. Functional magnetic resonance imaging and psychophysical assessments were utilized to compare the supraspinal events related to the spatial summation effect of three TG presentations: 20°C/20°C (G2020), 20°C/40°C (G2040) and 40°C/40°C (G4040) with corresponding matched thermode stimuli: 20°C (P20), 46°C (P46) and 40°C (P40) and hot pain (HP) stimuli. Results: For G2040, the hot burning sensation was only noted during the initial off-line assessment. In comparison to P40, G4040 resulted in an equally enhanced response from all supraspinal regions associated with both pain sensory/discriminatory and noxious modulatory response. In comparison to P20, G2020 presentation resulted in a much earlier diminished/sedative response leading to a statistically significantly (P < 0.01) higher degree of deactivation in modulatory supraspinal areas activated by G4040. Granger Causality Analysis showed that while thalamic activation in HP may cast activation inference in all hot pain related somatosensory, affective and modulatory areas, similar activation in G2040 and G2020 resulted in deactivation inference in the corresponding areas. Conclusions: In short, the transient TG sensation is caused by a dissociated state derived from non-noxious warm and cold spatial summation interaction. The observed central dissociated state may share some parallels in certain chronic neuropathic pain states.
其他題名： Mol Pain
出版者： Los Angeles, CA: SAGE Publications
出版日期： 2014-03-11
出處： Molecular pain, 2014-03, Vol.10 (1), p.18-18
資源來源： Sage Journals GOLD Open Access 2024
版權： 2014 Leung et al
版權： Leung et al.; licensee BioMed Central Ltd. 2014
版權： COPYRIGHT 2014 BioMed Central Ltd.
版權： 2014 Leung et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
版權： 2014 Leung et al. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
版權： Copyright © 2014 Leung et al.; licensee BioMed Central Ltd. 2014 Leung et al.; licensee BioMed Central Ltd.
識別號： ISSN: 1744-8069
識別號： EISSN: 1744-8069
識別號： DOI: 10.1186/1744-8069-10-18
識別號： PMID: 24612493 |
| 顯示於類別: | [認知與神經科學研究所 ] 期刊論文
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