Spectral analysis of cooling induced hemodynamic perturbations indicates involvement of sympathetic activation and nitric oxide production in rats

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Title:	Spectral analysis of cooling induced hemodynamic perturbations indicates involvement of sympathetic activation and nitric oxide production in rats
Authors:	李柏磊;Liu, Yia-Ping;Lin, Yi-Hsien;Chen, Yu-Chun;Lee, Po-Lei;Tung, Che-Se
Contributors:	資訊電機學院電機工程學系
Keywords:	anesthesia;Animals;Arterial Pressure;blood pressure;Cold stress;Cold-Shock Response;heart;Heart Rate;Male;Myogenic vascular responsiveness;Nitric oxide;Nitric Oxide - biosynthesis;Nitric Oxide - blood;pentobarbital;rats;Rats, Sprague-Dawley;Spectral analysis;Spectrum Analysis;Sympathetic activation;Sympathetic Nervous System - physiology;tachycardia
Date:	2015-07-11
Issue Date:	2026-04-23 14:41:35 (UTC+8)
Publisher:	Elsevier Inc.;Netherlands: Elsevier Inc
Abstract:	摘要： Oscillations in arterial pressure and heart period in response to cold stress are poorly understood. We used a telemetric device with spectral and cross-spectral analyses to assess variabilities in the heart rate (HRV) and blood pressure (BPV) of conscious rats receiving a cooling stimulus (CS) (rapid immersion of palms and soles into 4°C water) at ambient thermoneutral conditions (TC), in a cold room (CC), and when under pentobarbital anesthesia (UA). Power spectra of very low, low, and high frequencies (VLF: 0.02 to 0.2Hz, LF: 0.2 to 0.6Hz, and HF: 0.6 to 3.0Hz), dicrotic notch (Dn) and plasma nitric oxide (NO) levels were measured for statistical comparisons. When compared to resting rats (PreCS), CS evoked in rats the following hemodynamic perturbations: 1) pressor and tachycardia; 2) increases in VLFBPV, LFBPV, HFBPV, and TPBPV but decreases in VLFHRV, LFHRV, and TPHRV; 3) a positive correlation between LFBPV and VLFBPV but an inverse correlation between VLFHRV and VLFBPV and LFHRV and LFBPV; 4) high coherence value at frequency region of LF between BPV and HRV; and 5) increase of NO production and disappearance of Dn. Additionally, CS of CC and UA rats compared with TC rats evoked different patterns of hemodynamic perturbations; CC rats were activated but UA rats were inactivated. Our findings indicate that changes in VLFBPV are related to the myogenic vascular responsiveness to CS. Power spectra changes to CS are highly relevant to sympathetic activation and NO production. 其他題名： Life Sci 出版者： Netherlands: Elsevier Inc 出版日期： 2015-09-01 出處： Life sciences (1973), 2015-09, Vol.136, p.19-27 版權： 2015 Elsevier Inc. 版權： Copyright © 2015 Elsevier Inc. All rights reserved. 識別號： ISSN: 0024-3205 識別號： ISSN: 1879-0631 識別號： EISSN: 1879-0631 識別號： DOI: 10.1016/j.lfs.2015.06.011 識別號： PMID: 26141994
Appears in Collections:	[Department of Electrical Engineering] journal & Dissertation

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