摘要： By introducing a small backward dedifferentiation probability of postmitotic cells to progenitor cells in a recently proposed skin cell proliferation model, the homeostasis of the system can be disrupted resulting in uncontrolled growth. It is found that when the dedifferentiation probability exceeds a small critical value, the stable fixed point of the system vanishes leading to unlimited cell growth resembling scenarios in carcinogenesis. Explicit expression for the critical dedifferentiation probability and phase diagram are calculated analytically and the associated nonlinear dynamics is analyzed. In the presence of stochastic fluctuations, our model predicts that the escape rate from homeostatic growth to uncontrolled growth is greatly enhanced by a small but finite dedifferentiation probability. These results are verified by numerical solutions of the dynamical system and chemical Langevin equations. 其他題名： Phys Rev E Stat Nonlin Soft Matter Phys 出版者： United States 出版日期： 2012-04 出處： Physical review. E, Statistical, nonlinear, and soft matter physics, 2012-04, Vol.85 (4), p.041926, Article 041926 識別號： ISSN: 1539-3755 識別號： ISSN: 1550-2376 識別號： EISSN: 1550-2376 識別號： DOI: 10.1103/PhysRevE.85.041926 識別號： PMID: 22680517
