VBM Reveals Brain Volume differences between Parkinson's disease and essential tremor patients

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题名:	VBM Reveals Brain Volume differences between Parkinson's disease and essential tremor patients
作者:	段正仁;Lin, Ching-Hung;Chen, Chun-Ming;Lu, Ming-Kuei;Tsai, Chon-Haw;Chiou, Jin-Chern;Liao, Jan-Ray;Duann, Jeng-Ren
贡献者:	生醫理工學院認知神經科學研究所
关键词:	Anatomy;Atrophy;Basal Ganglia;Biomarkers;Brain architecture;Brain research;Cerebellum;Cerebral cortex;Essential Tremor;Middle temporal gyrus;Movement disorders;Neurodegenerative diseases;Neurology;Neuroscience;Parkinson's disease;Patients;Sensorimotor system;Studies;Thalamus;Tremor;voxel-based morphometry
日期:	2013-05-19
上传时间:	2026-04-23 14:50:48 (UTC+8)
出版者:	Switzerland: Frontiers Research Foundation
摘要:	摘要： Symptoms of essential tremor (ET) are similar to those of Parkinson's disease (PD) during their initial stages. Presently, there are few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, few investigations have directly compared the changes in brain volume and assessed the compensatory effects of a change in the parts of the brain associated with PD and with ET. To determine the compensatory and/or degenerative anatomical changes in the brains of PD and ET patients, the present study tested, via two voxel-based morphometry (VBM) approaches (Basic vs. DARTEL VBM processing), the anatomical brain images of 10 PD and 10 ET patients, as well as of 13 age-matched normal controls, obtained through a 3T magnetic resonance scanner. These findings indicate that PD and ET caused specific patterns of brain volume alterations in the brains examined. In addition, our observations also revealed compensatory effects, or self-reorganization, occurring in the thalamus and the middle temporal gyrus in the PD and ET patients, due perhaps in part to the enhanced thalamocortical sensorimotor interaction and the head-eye position readjustment, respectively, in these PD and ET patients. Such a distinction may lend itself to use as a biomarker for differentiating between these two diseases. 其他題名： Front Hum Neurosci 出版者： Switzerland: Frontiers Research Foundation 出版日期： 2013-06-14 出處： Frontiers in human neuroscience, 2013-06, Vol.7, p.247 資源來源： Directory of Open Access Journals 版權： 2013. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： Copyright © 2013 Lin, Chen, Lu, Tsai, Chiou, Liao and Duann. 2013 識別號： ISSN: 1662-5161 識別號： EISSN: 1662-5161 識別號： DOI: 10.3389/fnhum.2013.00247 識別號： PMID: 23785322
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