Endocardial Remodeling in Heart Failure Patients with Impaired and Preserved Left Ventricular Systolic Function-A Magnetic Resonance Image Study

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Title:	Endocardial Remodeling in Heart Failure Patients with Impaired and Preserved Left Ventricular Systolic Function-A Magnetic Resonance Image Study
Authors:	王淵弘;Lin, Lian-Yu;Su, Mao-Yuan M.;Pham, Van-Truong;Tran, Thi-Thao;Wang, Yung-Hung;Tseng, Wen-Yih I.;Lo, Men-Tzung;Lin, Jiunn-Lee
Contributors:	工學院機械工程學系
Keywords:	692/4019/592/1540;692/4019/592/75/230;Aged;Beta blockers;Cardiomegaly - diagnostic imaging;Cardiomegaly - metabolism;Cardiomegaly - pathology;Cardiomegaly - physiopathology;Cardiomyopathy;Contrast Media - metabolism;Female;Fibrosis;Gadolinium;Gadolinium DTPA - metabolism;Heart diseases;Heart failure;Heart Failure - diagnostic imaging;Heart Failure - metabolism;Heart Failure - pathology;Heart Failure - physiopathology;Humanities and Social Sciences;Humans;Hypertrophy;Image Enhancement;Magnetic resonance imaging;Magnetic Resonance Imaging - methods;Male;Middle Aged;multidisciplinary;Myocardium - metabolism;Myocardium - pathology;NMR;Nuclear magnetic resonance;Prospective Studies;Science;Stroke Volume;Ventricle;Ventricular Function, Left
Date:	2016-02-15
Issue Date:	2026-04-23 15:07:26 (UTC+8)
Publisher:	Nature Publishing Group;London: Nature Publishing Group UK
Abstract:	摘要： Left ventricular (LV) trabeculation has been studied in certain forms of cardiomyopathy. However, the changes of LV endocardial trabeculation during the remodeling process leading to heart failure (HF) are unclear. Seventy-four patients with systolic heart failure (SHF), 65 with heart failure with preserved ejection fraction (HFpEF) and 61 without HF were prospectively enrolled. All subjects received magnetic resonance imaging (MRI) study including cine, T1 and late gadolinium enhancement (LGE) images. Trabecular-papillary muscle (TPM) mass, fractal dimension (FD) and extracellular volume (ECV) were derived. The results showed that TPM mass index was higher in patients with SHF than that in patients with HFpEF and non-HF. The TPM mass-LV mass ratio (TPMm/LVM) was higher in SHF group than that in HFpEF and non-HF. FD was not different among groups. The presence of LGE was inversely associated with TPM mass index and TPMm/LVM while the ECV were positively associated with TPMm/LVM. The FD was positively associated with LV chamber size. In conclusion, TPM increases in patients with SHF and are probably related to myocardial cell hypertrophy and fibrotic repair during remodeling. The FD increases with the dilatation of LV chamber but remain unchanged with the deterioration of LV function. 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2016-02-15 出處： Scientific reports, 2016-02, Vol.6 (1), p.20868-20868, Article 20868 資源來源： Springer Nature Link (Free) 版權： The Author(s) 2016 版權： Copyright Nature Publishing Group Feb 2016 版權： Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep20868 識別號： PMID: 26876005
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