High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis

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题名:	High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis
作者:	曹嘉文;Tsao, Chia-Wen;Yang, Zhi-Jie
贡献者:	工學院機械工程學系
关键词:	desorption;gluconic acid;glucose;Glucose - analysis;Gold - chemistry;Humans;ionization;mass spectrometry;Metal Nanoparticles - chemistry;nanogold;Nanostructures - chemistry;silicon;Silicon - chemistry;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;urine
日期:	2015-10-14
上传时间:	2026-04-23 15:13:30 (UTC+8)
出版者:	American Chemical Society;United States: American Chemical Society
摘要:	摘要： Desorption/ionization on silicon (DIOS) is a high-performance matrix-free mass spectrometry (MS) analysis method that involves using silicon nanostructures as a matrix for MS desorption/ionization. In this study, gold nanoparticles grafted onto a nanostructured silicon (AuNPs-nSi) surface were demonstrated as a DIOS-MS analysis approach with high sensitivity and high detection specificity for glucose detection. A glucose sample deposited on the AuNPs-nSi surface was directly catalyzed to negatively charged gluconic acid molecules on a single AuNPs-nSi chip for MS analysis. The AuNPs-nSi surface was fabricated using two electroless deposition steps and one electroless etching step. The effects of the electroless fabrication parameters on the glucose detection efficiency were evaluated. Practical application of AuNPs-nSi MS glucose analysis in urine samples was also demonstrated in this study. 其他題名： ACS Appl. Mater. Interfaces 出版者： United States: American Chemical Society 出版日期： 2015-10-14 出處： ACS applied materials & interfaces, 2015-10, Vol.7 (40), p.22630-22637 資源來源： American Chemical Society Journals 版權： Copyright © 2015 American Chemical Society 識別號： ISSN: 1944-8244 識別號： ISSN: 1944-8252 識別號： EISSN: 1944-8252 識別號： DOI: 10.1021/acsami.5b07395 識別號： PMID: 26393877
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