Investigating cerebral oedema using poroelasticity

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題名:	Investigating cerebral oedema using poroelasticity
作者:	周鼎贏;Vardakis, John C.;Chou, Dean;Tully, Brett J.;Hung, Chang C.;Lee, Tsong H.;Tsui, Po-Hsiang;Ventikos, Yiannis
貢獻者:	工學院機械工程學系
關鍵詞:	Aquaporins;Biomechanical Phenomena;Brain Edema - diagnosis;Brain Edema - metabolism;Brain Edema - pathology;Brain Edema - surgery;Cerebral oedema;Computational Fluid Dynamics;Diseases;Elasticity;Endoscopic ventriculostomy;Finite Element Analysis;Finite Element Method;Fluids;Formations;Fourth Ventricular Outlet Obstruction;Gliosis;Humans;Hydrocephalus;Image Processing, Computer-Assisted;Interstitials;Intracranial Pressure;Magnetic Resonance Imaging;Male;Mathematical analysis;Mathematical models;Middle Aged;Models, Biological;Multiple-Network Poroelastic Theory;Periventricular lucency;Porosity;Radiology;Transport;Ventriculostomy
日期:	2016-01-01
上傳時間:	2026-04-23 15:16:23 (UTC+8)
出版者:	Elsevier BV;England: Elsevier Ltd
摘要:	摘要： •Multiple-Network Poroelastic Theory is used to develop a model of fluid regulation and tissue displacement.•The model is used to investigate interstitial cerebral oedema formation and its alleviation.•The model is applied separately using finite difference – CFD coupling and standalone FEM formulations.•Interstitial oedema due to fourth ventricle outlet obstruction can be observed to be alleviated via simulated endoscopic fourth ventriculostomy.•Periventricular lucency can be observed using the FEM based formulation. Cerebral oedema can be classified as the tangible swelling produced by expansion of the interstitial fluid volume. Hydrocephalus can be succinctly described as the abnormal accumulation of cerebrospinal fluid (CSF) within the brain which ultimately leads to oedema within specific sites of parenchymal tissue. Using hydrocephalus as a test bed, one is able to account for the necessary mechanisms involved in the interaction between oedema formation and cerebral fluid production, transport and drainage. The current state of knowledge about integrative cerebral dynamics and transport phenomena indicates that poroelastic theory may provide a suitable framework to better understand various diseases. In this work, Multiple-Network Poroelastic Theory (MPET) is used to develop a novel spatio-temporal model of fluid regulation and tissue displacement within the various scales of the cerebral environment. The model is applied through two formats, a one-dimensional finite difference – Computational Fluid Dynamics (CFD) coupling framework, as well as a two-dimensional Finite Element Method (FEM) formulation. These are used to investigate the role of endoscopic fourth ventriculostomy in alleviating oedema formation due to fourth ventricle outlet obstruction (1D coupled model) in addition to observing the capability of the FEM template in capturing important characteristics allied to oedema formation, like for instance in the periventricular region (2D model). 其他題名： Med Eng Phys 出版者： England: Elsevier Ltd 出版日期： 2016-01-01 出處： Medical engineering & physics, 2016-01, Vol.38 (1), p.48-57 版權： 2015 The Authors 版權： The Authors 版權： Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. 識別號： ISSN: 1350-4533 識別號： ISSN: 1873-4030 識別號： EISSN: 1873-4030 識別號： DOI: 10.1016/j.medengphy.2015.09.006 識別號： PMID: 26749338
顯示於類別:	[機械工程學系] 期刊論文

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