Numerical simulation of droplet-based microfluidic chip interfacing with laser desorption/ionisation mass spectrometry target substrate

NCUIR > Engineering College > Departmant of Mechanical Engineering > journal & Dissertation > Item 987654321/108987

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/108987

Title:	Numerical simulation of droplet-based microfluidic chip interfacing with laser desorption/ionisation mass spectrometry target substrate
Authors:	曹嘉文;Tsao, Chia-Wen;Chen, Ke-Siang;Hwang, Feng-Nan
Contributors:	工學院機械工程學系
Keywords:	biomarker identification;biomedical applications;bioMEMS;Computer simulation;droplet‐based microfluidic chip;drops;flow simulation;Formations;injection flow rates;inner microchannel surface wettability;Ionization;laser desorption‐ionisation mass spectrometry target substrate;Lasers;liquid‐gas phase;liquid‐liquid phase;MALDI mass spectra;Mass spectrometry;Mathematical models;microchannel flow;microdroplet dripping;microdroplet formation;Microfluidics;numerical analysis;numerical simulation;orifices (mechanical);outer orifice surface wettability;proteomics bioanalysis;two‐phase flow;Wettability;wetting
Date:	2015-01-01
Issue Date:	2026-04-23 15:19:22 (UTC+8)
Publisher:	Institution of Engineering and Technology;The Institution of Engineering and Technology
Abstract:	摘要： Droplet-based microfluidic devices have shown great potential in biomedical applications. When proteomics bioanalysis or biomarker identification is required, off-line microfluidic chip interfacing with mass spectrometry (MS) is necessary. This reported work has focused on the use of numerical simulation of microdroplet formation and dripping for a droplet-based microfluidic-chip interfacing with off-line laser desorption/ionisation MS target substrate. Unlike most studies on the microdroplet formation at the liquid–liquid phase, this work has investigated the microdroplet formation at the liquid–gas phase at various injection flow rates and inner microchannel surface wettability to meet microfluidic-chip–MS interfacing requirements. After the microdroplet formation, subsequent microdroplet dripping analysis was performed. The effects of inner microchannel and outer orifice surface wettability are discussed. 出版者： The Institution of Engineering and Technology 出版日期： 2015-04 出處： Micro & nano letters, 2015-04, Vol.10 (4), p.192-197 資源來源： Wiley Online Library Open Access 版權： The Institution of Engineering and Technology 版權： 2015 The Institution of Engineering and Technology 識別號： ISSN: 1750-0443 識別號： EISSN: 1750-0443 識別號： DOI: 10.1049/mnl.2014.0300
Appears in Collections:	[Departmant of Mechanical Engineering ] journal & Dissertation

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